e-cienciaDatos: "readme" form 

-------------------
GENERAL INFORMATION
-------------------
1. Title of dataset: Kynurenine pathway as a possible link between ethanol exposure produced behavioral alterations and neuroinflammation


2. Contact

   Principal Investigator Contact Information
        Name:Mª Isabel Colado Megía
        Institution:Universidad Complutense de Madrid
        Email:colado@ucm.es
	ORCID:0000-0003-4906-7559

3. Description of the project:This study suggests that chronic EtOH exposure induces neuroimmune activation, which may trigger KYN pathway activation and contribute to anxiety and memory deficits observed in the CIE model.


4. Description of the dataset:RNA sequencing and analysis


5. Notes


6. Deposit date:24/06/2025


7. Date


8. Language: English


--------------------------
AUTHOR INFORMATION
--------------------------
1. Author

        Name:Leticia
        Last name  :Gil de Biezma Elduayen
        Institution:Universidad Complutense de Madrid
        Email:letigild@ucm.es
	ORCID:



--------------------------
METHODOLOGY
--------------------------
1. Methodology:RNA-Seq 


2. Software: FastQC v0.11.7 


 
--------------------------
KEYWORDS
--------------------------
1. Keywords:ethanol, kynurenine, chronic intermittent ethanol (CIE), immune system, anxiety, memory



--------------------------
SPONSORSHIP INFORMATION AND GRANT IDs
--------------------------
1. Grant Information: Ministerio de Ciencia e Innovación (PID 2019-105847RB-I00; PID 2022-142137OB-I00), Ministerio de Sanidad [Plan Nacional Sobre Drogas (PNSD) Grants 2019I025, 2022I033, 2023I029],Instituto de Salud Carlos III RETIC RD16/0017/0021 and RIAPAd RD21/0009/0027

--------------------------
RELATED PUBLICATIONS
--------------------------
1. Related publication: Kynurenine pathway as a possible link between ethanol exposure produced behavioral alterations and neuroinflammation



2. Related dataset:
Gen-ID: gene identifier 
Transcript_ID:Specific isoform of a gen
Gene_Symbol:Abbreviation assigned to a gen
Description:Functional or strutural information about a gene or its product
gene_biotype:protein_coding (Gene that produces a functional protein)
Protein_ID:Protein a gen encodes
MGI:Mouse Genome Informatics database
IMGT/GENE-DB:Database from the International ImMunoGeneTics Information System®
Sample_FPKM:Fragments Per Kilobase of transcript per Million mapped reads
Sample_TPM:Transcripts Per Million.
X/Y_ACC.fc: Accepted Fold Change
X/Y_Acc.baseMean: Average normalized expression
X/Y_Acc.lfcSE: Accepted log fold change Standard Error
X/Y_Acc.stat: Accepted test statistic
X/Y_Acc.raw.pval: Accepted raw p-value
X/Y_Acc.bh.pval: Accepted Benjamini-Hochberg adjusted p-value
Sample_Acc.mean:Accepted mean expression
Sample_Acc_x_Read_Count number of reads mapped to a gene or transcript in sample x

--------------------------
GEOGRAPHIC INFORMATION
--------------------------
1. Spatial coverage


--------------------------
TEMPORAL INFORMATION
--------------------------
1. Time period coverage



--------------------------
FILES
--------------------------
1. Files 


--------------------------
LICENSES AND PRIVACITY
--------------------------
1. Licenses:Creative Commons Attribution License (CC BY)


2. Privacity


--------------------------
OTHERS
--------------------------
1. Data dictionary