Browsing by Author "Cuadrado Pérez, María Luz"
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PublicationDefining Post-COVID Symptoms (Post-Acute COVID, Long COVID, Persistent Post-COVID): An Integrative Classification(MPDI, 2021-03-05) Fernández-de-las-Peñas, César; Palacios-Ceña, Domingo; Gómez-Mayordomo, Víctor; Cuadrado Pérez, María Luz; Florencio, Lidiane L.The pandemic of the coronavirus disease 2019 (COVID-19) has provoked a second pandemic, the “long-haulers”, i.e., individuals presenting with post-COVID symptoms. We propose that to determine the presence of post-COVID symptoms, symptoms should appear after the diagnosis of SARS-CoV-2 infection; however, this situation has some problems due to the fact that not all people infected by SARS-CoV-2 receive such diagnosis. Based on relapsing/remitting nature of post-COVID symptoms, the following integrative classification is proposed: potentially infection related-symptoms (up to 4–5 weeks), acute post-COVID symptoms (from week 5 to week 12), long post-COVID symptoms (from week 12 to week 24), and persistent post-COVID symptoms (lasting more than 24 weeks). The most important topic is to establish the time reference points. The classification also integrates predisposing intrinsic and extrinsic factors and hospitalization data which could promote post-COVID symptoms. The plethora of symptoms affecting multiple systems exhibited by “long-haulers” suggests the presence of different underlying mechanisms. PublicationDesarrollo de recursos educativos y de un ecosistema de colaboración para la enseñanza de la Epidemiología y Salud Pública(2022-06-29) López de Andrés, Ana; Albaladejo Vicente, Romana; Cuadrado Pérez, María Luz; Elvira Martínez, Carlos María; Hernandez Jiménez,, José Antonio; Hoyos Miller, Juan Eduardo; Jiménez García, Rodrigo; Jiménez Trujillo, Isabel; Lopez de la Horra, Pablo; López Herranz, Marta; Miguel Díez, Javier de; Villanueva Orbáiz, María Rosa Rita; Zamorano León, José Javier; Jiménez Sierra, Lucía PublicationEvaluación del profesorado de Medicina en Práctica Clínica(2016-01-28) Álvarez-Sala Walther, Jose Luis; Álvarez-Sala Walther, Luis Antonio; Calvo Manuel, Elpidio; Fernández Galaz, Carmen; García Seoane, Jorge; López Gallardo, Meritxell; Cuadrado Pérez, María Luz; Martínez Hernández, David; Millán Núñez Cortés, Jesús; Ortega Molina, Paloma; Pérez de Oteiza, Carlos Antonio; Tejedor Jorge, Alberto; Villena Garrido, María Victoria PublicationFemale Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study(MPDI, 2022-01-14) Fernández de las Peñas, César; Martín Guerrero, José D.; Pellicer Valero, Óscar J.; Navarro Pardo, Esperanza; Gómez Mayordomo, Víctor; Cuadrado Pérez, María Luz; Arias Navalón, José A.; Cigarán Méndez, Margarita; Hernández Barrera, Valentín; Arendt Nielsen, LarsThis multicenter cohort study investigated the differences between coronavirus disease 2019 (COVID-19) related symptoms and post-COVID symptoms between male and female COVID-19 survivors. Clinical and hospitalization data were collected from hospital medical records in a sample of individuals recovered from COVID-19 at five public hospitals in Spain. A predefined list of post-COVID symptoms was systematically assessed, but patients were free to report any symptom. Anxiety/depressive levels and sleep quality were also assessed. Adjusted multivariate logistic regressions were used to identify the association of sex with post-COVID related-symptoms. A total of 1969 individuals (age: 61, SD: 16 years, 46.4% women) were assessed 8.4 months after discharge. No overall significant sex differences in COVID-19 onset symptoms at hospital admission were found. Post-COVID symptoms were present in up to 60% of hospitalized COVID-19 survivors eight months after the infection. The number of post-COVID symptoms was 2.25 for females and 1.5 for males. After adjusting by all variables, female sex was associated with ≥3 post-COVID symptoms (adj OR 2.54, 95%CI 1.671–3.865, p < 0.001), the presence of post-COVID fatigue (adj OR 1.514, 95%CI 1.040–2.205), dyspnea (rest: adj OR 1.428, 95%CI 1.081–1.886, exertion: adj OR 1.409, 95%CI 1.109–1.791), pain (adj OR 1.349, 95%CI 1.059–1.720), hair loss (adj OR 4.529, 95%CI 2.784–7.368), ocular problems (adj OR 1.981, 95%CI 1.185–3.312), depressive levels (adj OR 1.606, 95%CI 1.002–2.572) and worse sleep quality (adj OR 1.634, 95%CI 1.097–2.434). Female sex was a risk factor for the development of some long-term post-COVID symptoms including mood disorders. Healthcare systems should consider sex differences in the management of long haulers. PublicationSpatial Distribution of Temporalis Pressure Pain Sensitivity in Men with Episodic Cluster Headache(MDPI, 2019-11-01) Palacios-Ceña, María; Fuensalida-Novo, Stella; Cuadrado Pérez, María Luz; Ordás-Bandera, Carlos; Madeleine, Pascal; Fernández-de-las-Peñas, César; Guerrero, Ángel L.Background: Spatial changes in pressure sensitivity have been described in migraine and tension-type headaches. Our aim was to determine differences in the spatial distribution of pressure pain sensitivity of the temporalis muscle between cluster headache (CH) patients and headache-free controls. Methods: Pressure pain thresholds (PPTs) were determined over nine points covering the temporalis muscle in 40 men with episodic CH and 40 matched headache-free controls in a blinded fashion. Topographical pressure pain sensitivity maps were constructed based on interpolation of the PPTs. Patients were evaluated in a pain-free period (remission phase), at least 3 months from the last attack and without medication. Results: The analysis of covariance (ANCOVA) found significant difference between points (F = 21.887; P < 0.001) and groups (F = 24.416; P = 0.602), but not between sides (F = 0.440; P = 0.508). No effect of depression (F = 0.014; P = 0.907) or anxiety (F = 0.696; F = 0.407) was observed. A post-hoc analysis revealed: 1) lower PPTs at all points in patients than in controls, 2) an anterior-to-posterior gradient in patients but not in controls, with lower PPTs located in the anterior column. Large between-groups effects were shown in all points (standardized mean difference, SMD > 0.8). Conclusions: Bilateral pressure pain hypersensitivity to pressure pain in the temporalis muscle and an anterior-to-posterior gradient to pressure pain was observed in men with episodic CH.s.