Person:
Gil Dones, Félix

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First Name
Félix
Last Name
Gil Dones
URI
https://hdl.handle.net/20.500.14352/74303
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Biológicas
Department
Genética, Fisiología y Microbiología
Area
Genética
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Author: Martin-Rojas, Tatiana × Subject: 616-007.271 ×

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    A clinical perspective on the utility of alpha 1 antichymotrypsin for the early diagnosis of calcific aortic stenosis
    (Clinical Proteomics, 2017) Martin-Rojas, Tatiana; Mourino-Alvarez, Laura; Gil Dones, Félix; Cuesta, Fernando de la; Rosello-Lleti, Esther; Laborde, Carlos ; Rivera, Miguel; Lopez-Almodovar, Luis Fernando; Lopez, Juan Antonio; Akerstrom, Finn ; Padial, Luis ; Barderas, Maria
    Background: Calcific aortic stenosis (CAS) is the most common heart valve disease in the elderly, representing an important economic and social burden in developed countries. Currently, there is no way to predict either the onset or progression of CAS, emphasizing the need to identify useful biomarkers for this condition. Methods: We performed a multi-proteomic analysis on different kinds of samples from CAS patients and healthy donors: tissue, secretome and plasma. The results were validated in an independent cohort of subjects by immunohistochemistry, western blotting and selected reaction monitoring. Results: Alpha 1 antichymotrypsin (AACT) abundance was altered in the CAS samples, as confirmed in the validation phase. The significant changes observed in the amounts of this protein strongly suggest that it could be involved in the molecular mechanisms underlying CAS. In addition, our results suggest there is enhanced release of AACT into the extracellular fluids when the disease commences. Conclusions: The significant increase of AACT in CAS patients suggests it fulfils an important role in the physiopathology of this disease. These results permit us to propose that AACT may serve as a potential marker for the diagnosis of CAS, with considerable clinical value.