Person:
Moreno Jiménez, Florencio

First Name

Florencio

Last Name

Moreno Jiménez

URI

https://hdl.handle.net/20.500.14352/79918

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Óptica y Optometría

Department

Química Orgánica

Area

Química Orgánica

Identifiers

Full item page

Search Results

Now showing 1 - 10 of 11

Project number: 166
Determinantes del bajo rendimiento académico universitario: análisis del impacto de las variables previas al acceso a la universidad
(2022) García Fresnadillo, David; Constante Amores, Israel Alexander; Cuervo Rodríguez, María Rocío; Martínez Sánchez, Juan Carlos; Moreno Jiménez, Florencio; Ramírez Castellanos, Julio
Mejora del rendimiento académico en la asignatura Química de 1º de Grado en Química, Ing. Química, Optometría y Biología. Enfoque preventivo y diagnóstico. Análisis de factores (sociodemográficos, académicos y uso de TIC) al inicio de 1º curso.
Project number: 365
Influencia del cambio en la metodología de enseñanza-aprendizaje y de evaluación, de presencial a on-line, en el aprendizaje de contenidos, competencias y en el rendimiento académico de estudiantes de primer curso de grado de la UCM
(2021) García Fresnadillo, David; Cuervo Rodríguez, María Rocío; Moreno Jiménez, Florencio; Ramírez Castellanos, Julio; Arrieta Dillon, Marina Patricia; Constante Amores, Israel Alexander; Martínez Sánchez, Juan Carlos
Debido a Covid-19, el cambio en el modo de enseñar y evaluar al alumnado, con más énfasis en el campus virtual, afectará sensiblemente al curso 2020-2021. Se analiza la influencia sobre el aprendizaje y rendimiento académico de la asignatura Química en los estudiantes de 1º curso de varios grados de ciencias de la UCM.
Manipulating Charge-TransferStates in BODIPYs: A ModelStrategy to Rapidly Develop Photodynamic Theragnostic Agents
(Chemistry: a european journal, 2020) Jiménez González, Josué; Prieto Montero, Ruth; Lora Maroto, Beatriz; Moreno Jiménez, Florencio; Ortíz García, María Josefa; Oliden Sánchez, Ainhoa; López Arbeloa, Íñigo María; Martínez Martínez, Virginia; Moya Cerero, Santiago de la
On the basis of a family of BINOL (1,1′-bi-2-naphthol)-based O-BODIPY (dioxyboron dipyrromethene) dyes, it is demonstrated that chemical manipulation of the chromophoric push–pull character, by playing with the electron-donating capability of the BINOL moiety (BINOL versus 3,3'-dibromoBINOL) and with the electron-acceptor ability of the BODIPY core (alkyl substitution degree), is a workable strategy to finely balance fluorescence (singlet-state emitting action) versus the capability to photogenerate cytotoxic reactive oxygen species (triplet-state photosensitizing action). It is also shown that the promotion of a suitable charge-transfer character in the involved chromophore upon excitation enhances the probability of an intersystem crossing phenomenon, which is required to populate the triple state enabling singlet oxygen production. The reported strategy opens up new perspectives for rapid development of smarter agents for photodynamic theragnosis, including heavy-atom-free agents, from a selected organic fluorophore precursor.
BINOLated aminostyryl BODIPYs: a workable organic molecular platform for NIR circularly polarized luminescence
(Chemical Communications, 2021) Jiménez González, Josué; Díaz Norambuena, Carolina; Serrano Villar, Sergio; Ma, Shing Cho; Moreno Jiménez, Florencio; Maroto, Beatriz Lora; Bañuelos Prieto, Jorge; Muller, Gilles; Moya Cerero, Santiago de la
The accessible at-boron-BINOLated 3,5-bis(4-aminostyryl)ated BODIPY scaffold is highlighted as a workable platform for developing enantiopure small organic molecules exhibiting CPL in the NIR region, even in water solution, the latter being key for CPL-based bioapplications. Synthetic simplicity, noticeable chiroptical efficiency in the NIR and the possibility to access water-soluble emitters pave the way for advancing CPL tools based on organic emitters and NI radiation.
Multichromophoric COO-BODIPYs: an advantageous design for the development of energy transfer and electron transfer systems
(Chemical Communications, 2021) Ray Leiva, César; Schad, Christopher; Avellanal Zaballa, Edurne; Moreno Jiménez, Florencio; Maroto, Beatriz Lora; Bañuelos Prieto, Jorge; García Moreno, Inmaculada; Moya Cerero, Santiago de la
COO-BODIPYs are highlighted as cutting edge scaffolds for easy access to a new generation of multichromophoric architectures with enhanced (photo)chemical stability, showing either boosted capability for excitation energy transfer, glow fluorescence and laser emission, or photoinduced electron transfer. The new finding paves the way for the rapid development of smarter organic dyes for advancing photonics and optoelectronics
C*-BODIPYs: Exploring a New Strategy to Transfer Chirality towards BODIPY Chiroptics
(Proceedings, 2020) Jiménez González, Josué; Sánchez Camacho, Juan; Moreno Jiménez, Florencio; Rodríguez Agarrabeitia, Antonia; Arbeloa, Teresa; Cabreros, Trevor A.; Muller, Gilles; Bañuelos, Jorge; Maroto, Beatriz Lora; Moya Cerero, Santiago de la
C*-BODIPYs, that is, boron dipyrromethenes (BODIPYs) which have chiral carbons attached directly to the boron center, are introduced for the first time. These novel chiral BODIPYs mean a new strategy for the chiral perturbation of the inherently achiral BODIPY chromophore that is directed to enable chiroptical properties. Their preparation is very simple and only implies the complexation of a dipyrrin with an enantiopure dialkylborane having boron bonded to chiral carbons.
BCl3‑Activated Synthesis of COO-BODIPY Laser Dyes: General Scope and High Yields under Mild Conditions
(Journal of organic chemistry, 2020) Ray Leiva, César; Schad, Christopher; Moreno Jiménez, Florencio; Maroto, Beatriz Lora; Bañuelos Prieto, Jorge; Arbeloa, Teresa; García Moreno, Inmaculada; Villafuerte, Cassie; Muller, Gilles; Moya Cerero, Santiago de la
A general and straightforward method for the synthesis of COO-BODIPYs from F-BODIPYs and carboxylic acids is established. The method is based on the use of boron trichloride to activate the involved substitution of fluorine, which leads to high yields through rapid reactions under soft conditions. This mild method opens the way to unprecedented laser dyes with outstanding efficiencies and photostabilities, which are difficult to obtain by the current methods.
Project number: 30
Mentoría y aprendizaje significativo enfocado en estudiantes de primer curso de universidad: necesidades, expectativas y logros
(2021) Cuervo Rodríguez, María Rocío; García Fresnadillo, David; Moreno Jiménez, Florencio; Ramírez Castellanos, Julio; García Pereira, Francisco Javier; Martínez Sánchez, Juan Carlos; Arrieta Dillon, Marina Patricia; Schad Alburquerque, Cristobal Martín
'Desde el aprobado al no presentado. ¿Cuáles son las causas del abandono de una asignatura? Análisis de la asignatura Química de primer curso de grado en facultades de ciencias'
(2023) García Fresnadillo, David; Cuervo Rodríguez, María Rocío; Moreno Jiménez, Florencio; Ramírez Castellanos, Julio; Yang, Fan; Martínez Sánchez, Juan Carlos; Ribeiro González, Antonio; Agudo Blanco, Carlos; García Fresnadillo, David
La universidad española presenta un elevado porcentaje de estudiantes que abandonan la titulación que están cursando, o que muestran muy bajo rendimiento académico durante el primer curso de grado. Entre estos estudiantes hay que destacar un significativo número de estudiantes que abandonan ciertas asignaturas durante el curso académico, no presentándose a los exámenes finales (ordinario y extraordinario) de las mismas. El objetivo general del proyecto se centra en el estudio y análisis de los factores que, en el momento de entrada en la Universidad, están asociados al abandono de la asignatura de Química, con el propósito de llevar a cabo el diseño de un conjunto de acciones formativas destinadas a los estudiantes del primer curso del Grado en Óptica y Optometría, Grado en Ingeniería Química, Grado en Biología y Grado en Química, persiguiendo reducir la alta tasa de abandono de esta asignatura. Hay que tener presente que este trabajo se propone analizar las variables previas al acceso a la universidad, puesto que, únicamente de esta manera, se puede llevar a cabo un enfoque preventivo y diagnóstico.
Polar ammoniostyryls easily converting a clickable Q1 lipophilic BODIPY in an advanced plasma membrane probe†
(Journal of Materials Chemistry B, 2023) Serrano-Buitrago, Sergio; Muñoz Úbeda, Mónica; Almendro Vedia, Víctor Galileo; Sánchez-Camacho, Juan; Lora Maroto, Beatriz; Moreno, Florencio; Bañuelos, Jorge; García-Moreno, Inmaculada; López Montero, Iván; Moya Cerero, Santiago De La; Moreno Jiménez, Florencio
A very simple, small and symmetric, but highly bright, photostable and functionalizable molecular probe for plasma membrane (PM) has been developed from an accessible, lipophilic and clickable organic dye based on BODIPY. To this aim, two lateral polar ammoniostyryl groups were easily linked to increase the amphiphilicity of the probe and thus its lipid membrane partitioning. Compared to the BODIPY precursor, the transversal diffusion across lipid bilayers of the ammoniostyryled BODIPY probe was highly reduced, as evidenced by fluorescence confocal microscopy on model membranes built up as giant unilamellar vesicles (GUVs). Moreover, the ammoniostyryl groups endow the new BODIPY probe with the ability to optically work (excitation and emission) in the bioimaging-useful red region, as shown by staining of the plasma membrane of living mouse embryonic fibroblasts (MEFs). Upon incubation, this fluorescent probe rapidly entered the cell through the endosomal pathway. By blocking the endocytic trafficking at 4 °C, the probe was confined within the PM of MEFs. Our experiments show the developed ammoniostyrylated BODIPY as a suitable PM fluorescent probe, and confirm the synthetic approach for advancing PM probes, imaging and science.