Person:
Hernáiz Gómez-Degano, María Josefa

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First Name
María Josefa
Last Name
Hernáiz Gómez-Degano
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Orgánica
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Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

2018, Revuelta, Julia, Roberto Fuentes, Lagartera, Laura, Hernáiz Gómez-Degano, María Josefa, Bastida, Agatha, García-Junceda, Eduardo, Fernández-Mayoralas, Alfonso, Fernández-Mayoralas, Alfonso, Royal Society of London

A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.