Person:
Tejero Franco, Héctor

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First Name
Héctor
Last Name
Tejero Franco
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
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Area
Bioquímica y Biología Molecular
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Author: Tejero Franco, Héctor ×

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    Publication
    Mutación y extinción: de la catástrofe de error a la defección letal
    (Universidad Complutense de Madrid, 2013-01-16) Tejero Franco, Héctor; Montero Carnerero, Francisco
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    Publication
    The Advantage of Arriving First: Characteristic Times in Finite Size Populations of Error-Prone Replicators
    (Public Library of Science, 2013-12) Marín Aguacil, Arturo; Tejero Franco, Héctor; Nuño Sanz, Juan Carlos; Montero Carnerero, Francisco
    We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We interpret the results as the compromise between the characteristic time a lineage takes to reach its fittest phenotype by crossing the neutral valley and the selective value of the sequences that form the lineages. A main conclusion is drawn: for finite population sizes, the survival probability of the lineage that arrives first to the fittest phenotype rises significantly.