Person:
Roda Navarro, Pedro

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First Name
Pedro
Last Name
Roda Navarro
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
Area
Inmunología
Identifiers
UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

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Now showing 1 - 2 of 2
  • Publication
    Formación para la presentación y discusión de trabajos científicos en congresos
    (2022) García de Yébenes Mena, Virginia; Alegre Gómez, Sergio; Álvarez Corrales, Emigdio Arián; Fernández Boraita, Julia Belén; Guerra Pérez, Natalia; Roda Navarro, Pedro
    El proyecto tiene como objetivo proporcionar a los alumnos del máster de Investigación en Inmunología de la UCM una formación teórica y práctica para la presentación de trabajos científicos en congresos en formatos de presentación oral y en póster.
  • Publication
    Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production
    (MDPI, 2020-04-05) Aguilar Sopeña, Óscar; Hernández Pérez, Sara; Alegre Gómez, Sergio; Castro Sánchez, Patricia; Iglesias Ceacero, Alba; Lazo, John S.; Roda Navarro, Pedro
    We have previously shown the delivery of phosphatase of regenerating liver-1 (PRL-1) to the immunological synapse (IS) and proposed a regulatory role of the catalytic activity of PRLs (PRL-1, PRL-2 and PRL-3) in antigen-induced IL-2 production. Nonetheless, the expression in T cells and delivery to the IS of the highly homologous PRL-3, as well as the role of the catalytic activity of PRLs in antigen-induced early signaling, has not been investigated. Here, the expression of PRL-3 protein was detected in primary CD4 T cells and in the CD4 T cell line Jurkat (JK), in which an overexpressed GFP-PRL-3 fluorescent fusion protein trafficked through the endosomal recycling compartment and co-localized with PLCγ1 signaling sites at the IS. Pharmacological inhibition was used to compare the role of the catalytic activity of PRLs in antigen-induced early signaling and late IL-2 production. Although the phosphatase activity of PRLs was not critical for early signaling triggered by antigen, it seemed to regulate signaling dynamics and was necessary for proper IL-2 production. We propose that enzymatic activity of PRLs has a higher significance for cytokine production than for early signaling at the IS. However, further research will be necessary to deeply understand the regulatory role of PRLs during lymphocyte activation and effector function.