Person: Illescas Martínez, Beatriz María
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First Name
Beatriz María
Last Name
Illescas Martínez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Orgánica
Area
Química Orgánica
Identifiers
3 results
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Now showing 1 - 3 of 3
Item Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection(Journal of the American Chemical Society, 2018) Rodríguez Pérez, Laura; Ramos-Soriano, Javier; Pérez Sánchez, Alfonso; Illescas Martínez, Beatriz María; Muñoz, Antonio; Luczkowiak, Joanna; Lasala, Fátima; Rojo, Javier; Delgado Vázquez, Rafael; Martín León, NazarioSWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC “click chemistry” approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.Item Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses(Journal of the American Chemical Society, 2019) Ramos-Soriano, Javier; Reina, José ; Illescas Martínez, Beatriz María; de la Cruz, Noelia; Rodríguez Pérez, Laura; Lasala, Fátima; Rojo, Javier; Delgado, Rafael; Martín León, NazarioAfter the last epidemic of the Zika virus (ZIKV) in Brazil that peaked in 2016, growing evidence has been demonstrated of the link between this teratogenic flavivirus and microcephaly cases. However, no vaccine or antiviral drug has been approved yet. ZIKV and Dengue viruses (DENV) entry to the host cell takes place through several receptors, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), so that the blockade of this receptor through multivalent glycoconjugates supposes a promising biological target to inhibit the infection process. In order to get enhanced multivalency in biocompatible systems, tridecafullerenes appended with up to 360 1,2-mannobiosides have been synthesized using a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy. These systems have been tested against ZIKV and DENV infection, showing an outstanding activity in the picomolar range.Item Hexakis-adducts of [60]fullerene as molecular scaffolds of polynuclear spin-crossover molecules(Chemical Science, 2021) Palacios-Corella, Mario; Ramos-Soriano, Javier; Souto, Manuel; Ananias, Duarte; Calbo, Joaquín; Ortí, Enrique; Illescas Martínez, Beatriz María; Clemente-León, Miguel; Martín León, Nazario; Coronado, EugenioA family of hexakis-substituted [60]fullerene adducts endowed with the well-known tridentate 2,6-bis(pyrazol-1-yl)pyridine (bpp) ligand for spin-crossover (SCO) systems has been designed and synthesized. It has been experimentally and theoretically demonstrated that these molecular scaffolds are able to form polynuclear SCO complexes in solution. UV-vis and fluorescence spectroscopy studies have allowed monitoring of the formation of up to six Fe(II)–bpp SCO complexes. In addition, DFT calculations have been performed to model the different complexation environments and simulate their electronic properties. The complexes retain SCO properties in the solid state exhibiting both thermaland photoinduced spin transitions, as confirmed by temperature-dependent magnetic susceptibility and Raman spectroscopy measurements. The synthesis of these complexes demonstrates that [60]fullerene hexakis-adducts are excellent and versatile platforms to develop polynuclear SCO systems in which a fullerene core is surrounded by a SCO molecular shell.