Person: Illescas Martínez, Beatriz María
Loading...
First Name
Beatriz María
Last Name
Illescas Martínez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Orgánica
Area
Química Orgánica
Identifiers
3 results
Search Results
Now showing 1 - 3 of 3
Item Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection(Journal of the American Chemical Society, 2018) Rodríguez Pérez, Laura; Ramos-Soriano, Javier; Pérez Sánchez, Alfonso; Illescas Martínez, Beatriz María; Muñoz, Antonio; Luczkowiak, Joanna; Lasala, Fátima; Rojo, Javier; Delgado Vázquez, Rafael; Martín León, NazarioSWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC “click chemistry” approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.Item Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses(Journal of the American Chemical Society, 2019) Ramos-Soriano, Javier; Reina, José ; Illescas Martínez, Beatriz María; de la Cruz, Noelia; Rodríguez Pérez, Laura; Lasala, Fátima; Rojo, Javier; Delgado, Rafael; Martín León, NazarioAfter the last epidemic of the Zika virus (ZIKV) in Brazil that peaked in 2016, growing evidence has been demonstrated of the link between this teratogenic flavivirus and microcephaly cases. However, no vaccine or antiviral drug has been approved yet. ZIKV and Dengue viruses (DENV) entry to the host cell takes place through several receptors, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), so that the blockade of this receptor through multivalent glycoconjugates supposes a promising biological target to inhibit the infection process. In order to get enhanced multivalency in biocompatible systems, tridecafullerenes appended with up to 360 1,2-mannobiosides have been synthesized using a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy. These systems have been tested against ZIKV and DENV infection, showing an outstanding activity in the picomolar range.Item Enhanced Thermoelectricity in Metal–[60]Fullerene–Graphene Molecular Junctions(Nano Letters, 2023) Svatek, Simon; Sacchetti, Valentina; Rodríguez Pérez, Laura; Illescas Martínez, Beatriz María; Rincón-García, Laura; Rubio-Bollinger, Gabino; González, Maria Teresa; Bailey, Steven; Lambert, Colin; Martín León, Nazario; Agraït, NicolasThe thermoelectric properties of molecular junctions consisting of a metal Pt electrode contacting [60]fullerene derivatives covalently bound to a graphene electrode have been studied by using a conducting-probe atomic force microscope (c-AFM). The [60]fullerene derivatives are covalently linked to the graphene via two meta-connected phenyl rings, two para-connected phenyl rings, or a single phenyl ring.We find that the magnitude of the Seebeck coefficient is up to nine times larger than that of Au−C60−Pt molecular junctions.Moreover,the sign of the thermopower can be either positiveor negative depending on the details of the binding geometry and on the local value of the Fermi energy. Our results demonstrate the potential of using graphene electrodes for controlling and enhancing the thermoelectric properties of molecular junctions and confirm the outstanding performance of [60]fullerene derivatives.