Person:
Morales García, José Ángel

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First Name
José Ángel
Last Name
Morales García
URI
https://hdl.handle.net/20.500.14352/79584
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Biología Celular
Area
Histología
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2021 - 20234
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Author: Calleja Conde, Javier ×

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Now showing 1 - 4 of 4
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    Project number: 204
    Valoración de la aceptación y adquisición de competencias con el uso de atlas histológicos virtuales en el área de Histología
    (2022) Gómez Del Moral Martín-Consuegra, Manuel María; Katharina Buhle, Kora Mareen; Calleja Conde, Javier; Cortegano Jimeno, María Isabel; Echeverry Alzate, Victor; Giné Domínguez, Elena; Jiménez Canales, Francisco Javier; Martínez Mora, María Del Carmen; Sanz Miguel, María Del Carmen; Triguero Martínez, Ana; Morales García, José Ángel
    La pandemia aceleró el uso de herramientas virtuales. Nuestro departamento ha desarrollado atlas virtuales de Histología que empezamos a usar en prácticas con nuestros alumnos, junto a clases presenciales. Se hace necesaria una valoración de su uso.
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    Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
    (Addiction Biology, 2022) Calleja Conde, Javier; Morales García, José Ángel; Echeverry Alzate, Víctor; Bühler, Kora Mareen; Giné Domínguez, Elena; López Moreno, José Antonio
    Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5-HT2A receptors. Recently, the interest of psychedelics as pharmacological treatment for psychiatric disorders has increased significantly, including their use on problematic use of alcohol. This systematic review is aimed to analyse the last two decades of studies examining the relationship between classic psychedelics and alcohol consumption. We searched PubMed and PsycInfo for human and preclinical studies published between January 2000 to December 2021. The search identified 639 publications. After selection, 27 studies were included. Human studies (n = 20) generally show promising data and seem to indicate that classic psychedelics could help reduce alcohol consumption. Nevertheless, some of these studies present methodological concerns such as low number of participants, lack of control group or difficulty in determining the effect of classic psychedelics in isolation. On the other hand, preclinical studies (n = 7) investigating the effect of these compounds on voluntary alcohol consumption are scarce and show some conflicting data. Among these compounds, psilocybin seems to show the most consistent data indicating that this compound could be a potential candidate to treat alcohol use disorders. In the absence of understanding the biological and/or psychological mechanisms, more studies including methodological quality parameters are needed to finally determine the effects of classic psychedelics on alcohol consumption.
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    Project number: 374
    I Olimpiadas de Histología UCM. Aplicación del aprendizaje basado en juegos en el conocimiento de la Histología en el grado en Medicina
    (2023) Martínez Mora, María Del Carmen; Cuesta Rubio, Natalia; Sanz Miguel, María Del Carmen; Morales García, José Ángel; Giné Domínguez, Elena; Gómez Del Moral Martín-Consuegra, Manuel María; Cortegano Jimeno, María Isabel; López Moreno, José Antonio; Buhler, Kora Mareen Katharina; López Gómez, Ana; Jiménez Canales, Francisco Javier; Calleja Conde, Javier; Echeverry Alzate, Víctor Alfonso; Grijota Martínez, María Carmen
    El presente proyecto ha desarrollado una actividad de aprendizaje basado en juegos (Olimpiada de Histología) para asentar los contenidos de Histología Humana en el grado en Medicina, mediante una experiencia de aprendizaje activo divertida y motivadora.
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    The Immune System through the Lens of Alcohol Intake and Gut Microbiota
    (International Journal of Molecular Sciences, 2021) Calleja Conde, Javier; Echeverry Alzate, Víctor; Buhler, Kora Mareen Katharina; Durán González, Pedro; Morales García, José Ángel; Segovia Rodríguez, Lucía; Rodríguez De Fonseca, Fernando Antonio; Giné Domínguez, Elena; López Moreno, José Antonio
    The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.