Person: López Cabarcos, Enrique
Universidad Complutense de Madrid
Faculty / Institute
Química en Ciencias Farmacéuticas
Now showing 1 - 2 of 2
PublicationEffect of platelet-rich plasma on sinus lifting: a randomized-controlled clinical trial(Wiley-Blackwell, 2009) Torres García-Denche, Jesús; Tamimi, Faleh; Martinez, Pedro Pablo; Alkhraisat, Mohammad Hamdan; Linares, Rafael; Hernández, Gonzalo; Torres Macho, Juan; López Cabarcos, EnriqueObjective: The combination of anorganic bovine bone (ABB) with platelet-rich plasma (PRP)has been widely used in bone regeneration procedures although benefits are still unclear. The purpose of this study was to evaluate whether or not PRP improves the efficacy of ABB in sinus floor augmentation. In addition, we have investigated the effect of residual bone height and tobacco on implant survival in sinus augmentation procedures. Patient and methods: Eighty-seven patients recruited for this study under went 144 sinus floor augmentation procedures using ABB alone or ABB plus PRP (ABB +PRP) in a randomized clinical trial. A total of 286 implants were placed in the augmented bone, and their evolution was followed up for a period of 24 months. In order to investigate on a histological level and any adjunctive effects, we performed an ancillary study in five edentulous patients with a symmetrical severely resorbed maxilla. In these patients, a bilateral sinus augmentation was randomly performed using ABB or ABB+PRP in a splt-mouth design,and after 6 months, bone biopsies were taken from the implant sites for histological and histomorphometric analysis. Results: Overall, 96.2% of ABB and 98.6% of ABB+PRP implant sucess were obtained during the monitoring period and differences were not found between sites grafted with and without PRP in the 87 patients studied. Densitometry assessments and graft resorption were similar in both experimental groups. However, the histological and histomorphometrical analysis in the five edentulous patients revealed that bone augmentation was significantly higher in sites treated with ABB+PRP (p< o igual que 0.05). Another outcome from our study is that the lack of initial bone support (p< o igual que 0.05) and smoking (p=0.05) appeared to have a negative effect on the treatment success, which was accentuated when both circumstances coincided. Conclusions: PRP is not a determined factor for implant survival in sinus lifting procedures. However, this study revealed that PRP can improve the osteoconductive properties of ABB by increasing the volume of new bone formed. Moreover, in sinus augmentation procedures the implant's survival rate appears to be more influenced by the residual bone height or by tobacco than by the type of bone graft. PublicationBone augmentation in rabbit calvariae: comparative study between Bio-Oss® and a novel B-TCP/DCPD granulate(Wiley-Blackwell, 2006) Tamimi, Faleh; Torres García-Denche, Jesús; Tresguerres, Isabel; Clemente, Celia; López Cabarcos, Enrique; Blanco Jerez, LuisAim: In the present in vivo study, we compare the bone regeneration capacity of a novel brushite cement synthesized in our laboratory (DTG) with Bio-Oss® using rabbits as an animal model. Methods: The study was performed in a group of 14 adult New Zealand rabbits using the bone conduction model. Two titanium cylinders were fixed into perforated slits made on the parietal cortical bone of each rabbit. One cylinder was left empty (negative control) and the other was filled with either Bio-Oss® or brushite set cement granules (test cylinder). Four weeks after the intervention, the animals were sacrified and biopsies were taken. The following parameters were analysed: bone tissue augmentation, bone mineral density and biomaterials resorption. The comparison of data between the different groups was performed using the Mann-Whitney test with a significance level of p<0.05. Results: The mean bone mineral density and augmented mineral tissue inside the test cylinders were similar but higher than those of negative controls. Material resorption and bone tissue augmentation were significantly higher in the defects treated with the brushite-based set cement (p<0.05). Conclusions: Brushite cement granules were more resorbable and generated more bone tissue than Bio-Oss® inside the titanium cylinders placed in the rabbit calvaria.