Person:
Huerta Martínez, Luis Javier

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First Name
Luis Javier
Last Name
Huerta Martínez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Cirugía
Area
Cirugía
Identifiers
UCM identifierScopus Author IDDialnet ID

Search Results

Now showing 1 - 4 of 4
  • Publication
    Mejora de las habilidades comunicativas y el pensamiento crítico en estudiantes de Ciencias de la Salud mediante la combinación de flipped classroom (clase invertida) y debate formal
    (2019-06-30) Paredes Royano, Sergio Damián; Rancan, Lisa; Alonso González, Alberto; Asencio Pascual, José Manuel; García Martín, Mª Cruz; Garutti Martínez, Ignacio; Huerta Martínez, Luis Javier; Marañón Pardillo, Gonzalo; Simón Adiego, Carlos Mª; Valdés López-Linares, Sergio; Valdivielso Suárez, Elena; Zueco Alegre, José Antonio; Vara Ameigeiras, Elena Mª
    Se propone la clase invertida (flipped classroom) y el debate formal como metodologías innovadoras para mejorar las habilidades comunicativas y el pensamiento crítico en respuesta a la demanda de tener futuros profesionales biomédicos mejor formados en estos ámbitos.
  • Publication
    Respuesta hepática durante la isquemia-reperfusión pulmonar modulada con precondicionamiento isquémico en un modelo experimental de autotrasplante pulmonar en cerdo
    (Universidad Complutense de Madrid, 2017-02-09) Huerta Martínez, Luis Javier; Simón Adiego, Carlos; González Aragoneses, Federico; Vara Amegeiras, Elena
    El daño por isquemia-reperfusión es reconocido como un serio problema que acompaña a diversos procedimientos médicos y quirúrgicos habituales tales como la terapia trombolítica, el trasplante de órganos, la angioplastia coronaria y el by-pass cardiopulmonar. La isquemia-reperfusión pulmonar induce una respuesta inflamatoria local en el propio parénquima pulmonar caracterizada por daño alveolar inespecífico, edema pulmonar e hipoxemia. La isquemia-reperfusión pulmonar también induce una respuesta inflamatoria sistémica con afectación de órganos remotos, la cual es incluso más dañina que sus efectos locales. Estudios previos han demostrado en modelos clínicos y experimentales que el hígado es particularmente sensible a la liberación de mediadores inflamatorios, hecho que ocurre tras la isquemia-reperfusión de órganos remotos tales como: riñón, intestino y músculo esquelético. Se ha comprobado que el precondicionamiento isquémico directo es capaz de proteger a diversos órganos frente al daño por isquemia-reperfusión. Nuestro grupo ha demostrado previamente en un modelo de autotrasplante pulmonar en cerdo, que el precondicionamiento isquémico atenúa el daño por isquemia-reperfusión pulmonar mediante la prevención del aumento de los metabolitos de peroxidación lipídica, la activación leucocitaria y las citoquinas proinflamatorias en el parénquima pulmonar...
  • Publication
    Effects of Intraoperative Infusion of Esmolol on Systemic and Pulmonary Inflammation in a Porcine Experimental Model of Lung Resection Surgery
    (International Anesthesia Research Society, 2019-01) Abubakra, Selma; Ortega, Javier; Garutti Martínez, Ignacio; Rancán, Lisa; Simón Adiego, Carlos María; Paredes Royano, Sergio Damián; Huerta Martínez, Luis Javier; Nieva Ramos, Silvia; Vara Ameigeiras, Elena María
    Abstract BACKGROUND: Lung resection surgery (LRS) is associated with systemic and pulmonary inflammation, which can affect postoperative outcomes. Activation of β-adrenergic receptors increases the expression of proinflammatory and anti-inflammatory mediators, and their blockade may attenuate the systemic inflammatory response. The aim of this study was to analyze the effect of a continuous perioperative intravenous perfusion of esmolol on postoperative pulmonary edema in an experimental model of LRS requiring periods of one-lung ventilation (OLV). METHODS: Twenty-four large white pigs were randomly assigned to 3 groups: control (CON), esmolol (ESM), and sham. The ESM group received an intravenous esmolol bolus (0.5 mg/kg) and then an esmolol infusion (0.05 mg·kg−1·minute−1) throughout the procedure. The CON group received the same volume of 0.9% saline solution as the ESM group plus a continual infusion of saline. The sham group underwent a left thoracotomy without LRS or OLV. At the end of the LRS, the animals were awakened, and after 24 hours, they underwent general anesthesia again. Lung biopsies and plasma samples were obtained to analyze the levels and expression of inflammatory mediators, and the animals also received a bronchoalveolar lavage. RESULTS: At 24 hours after the operation, the ESM group had less lung edema and lower expression of the proinflammatory biomarkers tumor necrosis factor (TNF) and interleukin (IL)-1 compared to the CON group for both lung lobes. For the mediastinal lobe biopsies, the mean difference and 95% confidence interval (CI) between the groups for edema, TNF, and IL-1 were 14.3 (95% CI, 5.6–23.1), P = .002; 0.19 (95% CI, 0.07–0.32), P = .002; and 0.13 (95% CI, 0.04–0.22), P = .006, respectively. In the left upper lobe, the mean differences for edema, TNF, and IL-1 were 12.4 (95% CI, 4.2–20.6), P = .003; 0.25 (95% CI, 0.12–0.37), P < .001; and 0.3 (95% CI, 0.08–0.53), P = .009. CONCLUSIONS: Our results suggest that esmolol reduces lung edema and inflammatory responses in the intraoperative and postoperative periods in animals that underwent LRS with OLV.
  • Publication
    Effects of Intraoperative Infusion of Esmolol on Systemic and Pulmonary Inflammation in a Porcine Experimental Model of Lung Resection Surgery.
    (Lippincott, Williams & Wilkins, 2019-01-01) Garutti Martínez, Ignacio; Rancán, Lisa; Abubakra, S; Simón Adiego, Carlos María; Paredes Royano, Sergio Damián; Ortega, J; Huerta Martínez, Luis Javier; Ramos, S; Vara Ameigeiras, Elena María
    Background: Lung resection surgery (LRS) is associated with systemic and pulmonary inflammation, which can affect postoperative outcomes. Activation of β-adrenergic receptors increases the expression of proinflammatory and anti-inflammatory mediators, and their blockade may attenuate the systemic inflammatory response. The aim of this study was to analyze the effect of a continuous perioperative intravenous perfusion of esmolol on postoperative pulmonary edema in an experimental model of LRS requiring periods of one-lung ventilation (OLV). Methods: Twenty-four large white pigs were randomly assigned to 3 groups: control (CON), esmolol (ESM), and sham. The ESM group received an intravenous esmolol bolus (0.5 mg/kg) and then an esmolol infusion (0.05 mg·kg·minute) throughout the procedure. The CON group received the same volume of 0.9% saline solution as the ESM group plus a continual infusion of saline. The sham group underwent a left thoracotomy without LRS or OLV. At the end of the LRS, the animals were awakened, and after 24 hours, they underwent general anesthesia again. Lung biopsies and plasma samples were obtained to analyze the levels and expression of inflammatory mediators, and the animals also received a bronchoalveolar lavage. Results: At 24 hours after the operation, the ESM group had less lung edema and lower expression of the proinflammatory biomarkers tumor necrosis factor (TNF) and interleukin (IL)-1 compared to the CON group for both lung lobes. For the mediastinal lobe biopsies, the mean difference and 95% confidence interval (CI) between the groups for edema, TNF, and IL-1 were 14.3 (95% CI, 5.6-23.1), P = .002; 0.19 (95% CI, 0.07-0.32), P = .002; and 0.13 (95% CI, 0.04-0.22), P = .006, respectively. In the left upper lobe, the mean differences for edema, TNF, and IL-1 were 12.4 (95% CI, 4.2-20.6), P = .003; 0.25 (95% CI, 0.12-0.37), P < .001; and 0.3 (95% CI, 0.08-0.53), P = .009. Conclusions: Our results suggest that esmolol reduces lung edema and inflammatory responses in the intraoperative and postoperative periods in animals that underwent LRS with OLV.