Person:
Sánchez Ramón, Silvia María

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First Name
Silvia María
Last Name
Sánchez Ramón
URI
https://hdl.handle.net/20.500.14352/79089
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
Area
Inmunología
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Author: Brandi, Paola × Subject: 577.1 ×

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    Human dendritic cells activated with MV130 induce Th1, Th17 and IL-10 responses via RIPK2 and MyD88 signalling pathways
    (European Journal of Immunology, 2018) Cirauqui, Cristina; Benito Villalvilla, Cristina; Sánchez Ramón, Silvia María; Sirvent, Sofía; Diez Rivero, Carmen María; Conejero, Laura; Brandi, Paola; Hernández Cillero, Lourdes; Ochoa, Juliana Lucía; Pérez Villamil, Beatriz; Sancho, David; Subiza Garrido-Lestache, José Luis; Palomares Gracia, Óscar
    Recurrent respiratory tract infections (RRTIs) are the first leading cause of community- and nosocomial-acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore, the development of new alternative approaches to prevent and treat RRTIs is highly demanded. Daily sublingual administration of the whole heat-inactivated polybacterial preparation (PBP) MV130 significantly reduced the rate of respiratory infections in RRTIs patients, however, the immunological mechanisms of action remain unknown. Herein, we study the capacity of MV130 to immunomodulate the function of human dendritic cells (DCs) as a potential mechanism that contribute to the clinical benefits. We demonstrate that DCs from RRTIs patients and healthy controls display similar ex vivo immunological responses to MV130. By combining systems biology and functional immunological approaches we show that MV130 promotes the generation of Th1/Th17 responses via receptor-interacting serine/threonine-protein kinase-2 (RIPK2)- and myeloid-differentiation primary-response gene-88 (MyD88)-mediated signalling pathways under the control of IL-10. In vivo BALB/c mice sublingually immunized with MV130 display potent systemic Th1/Th17 and IL-10 responses against related and unrelated antigens. We elucidate immunological mechanisms underlying the potential way of action of MV130, which might help to design alternative treatments in other clinical conditions with high risk of recurrent infections.