Aviso: antes de depositar, asegúrate que el documento no está ya en el repositorio. Para ello busca por el título: escribe solo la primera parte y excluye los dos puntos, guiones, etc. y la frase posterior.
Para depositar documentos, por favor, inicia sesión e identifícate con tu cuenta de correo institucional de la UCM con el botón MI CUENTA UCM. No emplees la opción AUTENTICACIÓN CON CONTRASEÑA
(Type 2 Diabetes - From Pathophysiology to Cyber Systems, 2021) Hurtado Carneiro, Verónica; Pérez García, Ana; Álvarez García, Elvira; Sanz Miguel, María Del Carmen; Anca Pantea Stoian
Cell survival depends on the constant challenge to match energy demands with nutrient availability. This process is mediated through a highly conserved network of metabolic fuel sensors that orchestrate both a cellular and whole-body energy balance. A mismatch between cellular energy demand and nutrient availability is a key factor in the development of type 2 diabetes, obesity, metabolic syndrome, and other associated pathologies; thus, understanding the fundamental mechanisms by which cells detect nutrient availability and energy demand may lead to the development of new treatments. This chapter reviews the role of the sensor PASK (protein kinase with PAS domain), analyzing its role in the mechanisms of adaptation to nutrient availability and the metabolic response in different organs (liver, hypothalamus) actively cooperating to control food intake, maintain glycaemia homeostasis, and prevent insulin resistance and weight gain.