Person:
Alonso Gómez, José Miguel

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First Name
José Miguel
Last Name
Alonso Gómez
URI
https://hdl.handle.net/20.500.14352/76150
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Orgánica
Area
Química Orgánica
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2022 - 20232
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Author: Aragoncillo Abanades, Cristina × Subject: 547 ×

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    2,3‐Diodocarbazoles by a domino iodocyclization/iodo‐translocation of (3‐iodoindolyl)butynols
    (Advance Synthesis & Catalysis, 2022) Martín‐Mejías, Irene; Petcu, Sonia; Alonso Gómez, José Miguel; Aragoncillo Abanades, Cristina; Almendros Requena, Pedro
    A controlled access to 1‐aryl 2,3‐diiodo‐carbazoles involving iodine transposition has been accomplished directly from acyclic precursors. The 2,3‐diiodo‐carbazole core was prone to further chemoselective decoration at C3−I or double difunctionalization.
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    Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates
    (Journal of Organic Chemistry, 2023) Petcu, Sonia; Lázaro Milla, Carlos; Rodríguez, Javier; Iriepa, Isabel; Bautista-Aguilera, Óscar ; Aragoncillo Abanades, Cristina; Alonso Gómez, José Miguel; Almendros Requena, Pedro
    Herein, we report a facile isocoumarin and isoquinolone preparation by taking advantage of an initial bis(triflyl)ethylation [triflyl = (trifluoromethyl)sulfonyl] reaction, followed by heterocyclization, which contrasts with our previous results on cyclobutene formation. The efficiency of the catalyst- and irradiation-free heterocyclization/bis(triflyl)ethylation sequence showed exquisite dependence on the electronic nature of the substituents at the 2-ethynylbenzoate(benzamide) precursors. Molecular docking of model bis(triflyl)ethylated isocoumarins on human acetylcholinesterase (hAChE) revealed promising biological activities through selective coordination on both the catalytic active site and peripheral active site.