Person: Zuluaga Arias, María Del Pilar
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First Name
María Del Pilar
Last Name
Zuluaga Arias
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Estadística e Investigación Operativa
Area
Estadística e Investigación Operativa
Identifiers
3 results
Search Results
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Item Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study(Clinical Neurophysiology, 2018) De Frutos Lucas, Jaisalmer; López Sanz, David; Zuluaga Arias, María Del Pilar; Rodríguez Rojo, Inmaculada Concepción; Cazorla Luna, Raúl; López García, María Eugenia; Delgado Losada, María Luisa; Marcos Dolado, Alberto; Barabash Bustelo, Ana; López Sánchez, Ramón; Maestu Unturbe, Fernando; Fernández Lucas, Alberto AmableObjective Since a cure for Alzheimer’s Disease (AD) is yet to be discovered, attention has shifted towards prevention. Physical activity (PA) emerged as a notorious lifestyle factor that could influence brain structure and function. The individual alpha peak frequency (IAPF) is a measure that summarizes the spectral content of brain signals and has been proven to be sensitive to both AD pathology and PA interventions. Therefore, our goal was to unravel whether chronic PA modulates IAPF and if APOE ɛ4 carriage moderates this relationship. Methods We analyzed 4-minutes of resting-state magnetoencephalographic recordings from 100 healthy elders that provided self-reported measures of PA, and the IAPF was calculated. Results We found that IAPF was negatively influenced by age and APOE and positively influenced by PA. The effect of PA on IAPF only remained significant for the ɛ4 non-carriers group. Conclusions PA is positively associated to higher IAPF in healthy older adults and could potentially act as a protective factor against cognitive decline. Nevertheless, such effect is non-significant among elders who are more vulnerable to developing AD due to their genetic carriage. Significance This investigation offers the first neurophysiological evidences on the combined effects of APOE genotype and PA in healthy elders.Item Brain signal complexity in adults with Down syndrome: Potential application in the detection of mild cognitive impairment(Frontiers in Aging Neuroscience, 2022) Fernández Lucas, Alberto Amable; Ramírez Toraño, Federico; Bruña Fernández, Ricardo; Zuluaga Arias, María Del Pilar; Esteba Castillo, Susanna; Abásolo, Daniel; Moldenhauer, Fernando; Shumbayawonda, Elizabeth; Maestu Unturbe, Fernando; García Alba, JavierBackground: Down syndrome (DS) is considered the most frequent cause of early-onset Alzheimer’s disease (AD), and the typical pathophysiological signs are present in almost all individuals with DS by the age of 40. Despite of this evidence, the investigation on the pre-dementia stages in DS is scarce. In the present study we analyzed the complexity of brain oscillatory patterns and neuropsychological performance for the characterization of mild cognitive impairment (MCI) in DS. Materials and methods: Lempel-Ziv complexity (LZC) values from restingstatemagnetoencephalography recordings and the neuropsychological performance in 28 patients with DS [control DS group (CN-DS) (n = 14), MCI group (MCI-DS) (n = 14)] and 14 individuals with typical neurodevelopment (CN-no-DS) were analyzed. Results: Lempel-Ziv complexity was lowest in the frontal region within the MCI-DS group, while the CN-DS group showed reduced values in parietal areas when compared with the CN-no-DS group. Also, the CN-no-DS group exhibited the expected pattern of significant increase of LZC as a function of age, while MCI-DS cases showed a decrease. The combination of reduced LZC values and a divergent trajectory of complexity evolution with age, allowed the discrimination of CN-DS vs. MCI-DS patients with a 92.9% of sensitivity and 85.7% of specificity. Finally, a pattern of mnestic and praxic impairment was significantly associated in MCI-DS cases with the significant reduction of LZC values in frontal and parietal regions (p = 0.01). Conclusion: Brain signal complexity measured with LZC is reduced in DS and its development with age is also disrupted. The combination of both features might assist in the detection of MCI within this population.Item Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography(Journal of Psychiatry and Neuroscience, 2005) Fernández Lucas, Alberto Amable; Rodríguez Palancas, Alfonso; López-Ibor Alcocer, María Inés; Zuluaga Arias, María Del Pilar; Turrero Nogués, Agustín; Maestu Unturbe, Fernando; Amo, Carlos; López-Ibor Aliño, Juan José; Ortiz, TomásObjective: To test the hypothesis that there is increased low-frequency activity located predominantly in the frontal lobe in patients with major depressive disorder using magnetoencephalography. Methods: We carried out an unmatched or separate sampling case-control study of 31 medication-free patients who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria for major depressive disorder and were outpatients of the Hospital Central de la Defensa, Madrid, and 22 healthy control subjects with no history of mental illness. A logistic regression analysis was employed to examine the predictive value of magnetoencephalography dipole density scores in the diagnosis of depression. We attempted to locate generators of focal magnetic slow waves by employing a single moving dipole model and by calculating dipole densities in prefrontal, frontal, parietal, temporal and occipital areas. The study lasted from February 2001 to January 2003. Results: Only 2 dipole density scores, right occipital delta and left temporal delta, were significantly related to depression. According to the comparison of univariate and multivariate models and odds ratios, the right occipital delta dipole density is the factor with the greatest predictive power for depression, and the only one to show a significant correlation with severity of depression. Conclusions: We did not find any frontal lobe functional alteration. Our study provides, to the best of our knowledge, the first evidence of abnormal focal magnetic low-frequency activity in the occipital lobe of untreated patients with depression. Increased occipital lobe delta dipole density seems to be a reliable risk factor for depression, which correlates with disease severity according to the Hamilton Rating Scale for Depression.