Person: Zuluaga Arias, María Del Pilar
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First Name
María Del Pilar
Last Name
Zuluaga Arias
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Estadística e Investigación Operativa
Area
Estadística e Investigación Operativa
Identifiers
7 results
Search Results
Now showing 1 - 7 of 7
- Project number: 443
Item El formato vídeo como herramienta para el aprendizaje de la Histología. Implementación de “HistoApp” para la autoevaluación individual y asistida del alumno como refuerzo para el aprendizaje(2023) Buño Borde, Ismael; Sacedón Ayuso, Rosa; Novillo Villajos, Apolonia; Jiménez Pérez, Eva; Zuluaga Arias, María Del Pilar; Escribano Martínez, Catalina; Orera Clemente, María Asunción; Ortega Salmerón, Lucía; Buño Borde, Ismael Item Unveiling the value of C-reactive Protein as a Severity Biomarker and the IL4/IL13 Pathway as a Therapeutic Target in Recessive Dystrophic Epidermolysis Bullosa: a multiparametric cross-sectional study(Experimental Dermatology, 2024) Quintana Castanedo, Lucía; Sánchez Ramón, Silvia María; Illera, Nuria; Zuluaga Arias, María Del Pilar; Martínez Santamaría, Lucía; Fernández Arquero, Miguel; Río, Marcela del; Vicente López, María Ángeles; Escámez, María José; Sacedón Ayuso, RosaPatients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and infection. Understanding the immunological mechanisms is crucial for selecting medications that balance inflammation control and immunocompetence. In this cross-sectional study, aiming to identify potential immunotherapeutic targets and inflammatory biomarkers, we delved into the interrelationship between clinical severity and systemic inflammatory parameters in a representative RDEB cohort. Encompassing 84 patients aged 1 to 67 and spanning all three Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) severity categories, we analyzed the interrelationship of infection history, standard inflammatory markers, systemic cytokines, and Ig levels to elucidate their roles in RDEB pathophysiology. Our findings identify C-reactive protein as an excellent biomarker for disease severity in RDEB. A Type 2 inflammatory profile prevails among moderate and severe RDEB patients, correlating with dysregulated circulating IgA and IgG. These results underscore the IL4/IL13 pathways as potential evidence-based therapeutic targets. Moreover, the complete inflammatory scenario aligns with Staphylococcus aureus virulence mechanisms. Concurrently, abnormalities in IgG, IgE, and IgM levels suggest an immunodeficiency state in a substantial number of the cohort's patients. Our results provide new insights into the interplay of infection and immunological factors in the pathogenesis of RDEB.Item Self-perception of the acquisition of transferable competencies by the participants in a research congress for undergraduate students: A cross-sectional study(Heliyon, 2024) Arráez Aybar, Luis Alfonso; Arias Díaz, Javier; Paredes Royano, Sergio Damián; Zuluaga Arias, María Del Pilar; Chevalier Del Río, Margarita; García Martín, Elena Salobrar; Collado Yurrita, Luis Rodolfo; Hurtado Moreno, Olivia; Fernández Mateos, María Del PilarContext: Several curricular initiatives have been developed to improve the acquisition of research competencies by Health Science students. Objectives: To know how students self-perceived of whether their participation in the XIV National Research Congress for Undergraduate Students of Health Sciences had helped them in the acquisition of 36 research-related transferable competencies (TCs) common to Health Science degrees. Methods: A survey design (Cronbach's alpha = 0.924), using a self-administered questionnaire, was conducted among undergraduate students who voluntarily participated in the Congress. Data analysis was performed using SPSS 25 and Statgraphics 19. Statistical significance was considered for P < 0.05. Results: Eighty-one students from 12 Health Science degree programs responded. Key findings are presented in a structured manner, using a Likert-5 scale. Twenty-five of the competencies surveyed obtained an average ≥ 4 highlighting: "Critically evaluate and know how to use sources of clinical and biomedical information to obtain, organize, interpret, and communicate scientific and health information"; "To be able to formulate hypotheses, collect and critically evaluate information for problem solving, following the scientific method", "Critical analysis and research" and "Communicate effectively and clearly, orally and in writing with other professionals". Significance was found in 15 competencies. The development of the competencies "Teamwork", "Critical reasoning" and "Analysis and synthesis abilities" was considered to be of greater "personal utility" by the respondents. Conclusion: Participation in this event contributed to the development of research-related TCs, critical analysis and information management and communication, especially in relation to learning the sources of clinical and biomedical information, to know, following the scientific method, how to formulate hypotheses that allow students to solve problems in their professional activity. The experience was significantly influenced by the respondents' year, the type of participation in the event and the gender of the students. Limitations and suggestions regarding future research are discussed to encourage further exploration of the topic.Item Brain signal complexity in adults with Down syndrome: Potential application in the detection of mild cognitive impairment(Frontiers in Aging Neuroscience, 2022) Fernández Lucas, Alberto Amable; Ramírez Toraño, Federico; Bruña Fernández, Ricardo; Zuluaga Arias, María Del Pilar; Esteba Castillo, Susanna; Abásolo, Daniel; Moldenhauer, Fernando; Shumbayawonda, Elizabeth; Maestu Unturbe, Fernando; García Alba, JavierBackground: Down syndrome (DS) is considered the most frequent cause of early-onset Alzheimer’s disease (AD), and the typical pathophysiological signs are present in almost all individuals with DS by the age of 40. Despite of this evidence, the investigation on the pre-dementia stages in DS is scarce. In the present study we analyzed the complexity of brain oscillatory patterns and neuropsychological performance for the characterization of mild cognitive impairment (MCI) in DS. Materials and methods: Lempel-Ziv complexity (LZC) values from restingstatemagnetoencephalography recordings and the neuropsychological performance in 28 patients with DS [control DS group (CN-DS) (n = 14), MCI group (MCI-DS) (n = 14)] and 14 individuals with typical neurodevelopment (CN-no-DS) were analyzed. Results: Lempel-Ziv complexity was lowest in the frontal region within the MCI-DS group, while the CN-DS group showed reduced values in parietal areas when compared with the CN-no-DS group. Also, the CN-no-DS group exhibited the expected pattern of significant increase of LZC as a function of age, while MCI-DS cases showed a decrease. The combination of reduced LZC values and a divergent trajectory of complexity evolution with age, allowed the discrimination of CN-DS vs. MCI-DS patients with a 92.9% of sensitivity and 85.7% of specificity. Finally, a pattern of mnestic and praxic impairment was significantly associated in MCI-DS cases with the significant reduction of LZC values in frontal and parietal regions (p = 0.01). Conclusion: Brain signal complexity measured with LZC is reduced in DS and its development with age is also disrupted. The combination of both features might assist in the detection of MCI within this population.Item Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum(GeroScience, 2022) Fernández Lucas, Alberto Amable; Vaquero Zamora, Lucía; Bajo Bretón, Ricardo; Zuluaga Arias, María Del PilarWhether the deleterious efects of APOE4 are restricted to the Alzheimer’s disease (AD) spectrum or cause cognitive impairment irrespectively of the development of AD is still a matter of debate, and the focus of this study. Our analyses included APOE4 genotype, neuropsychological variables, amyloid-βeta (Aβ) and Tau markers, FDG-PET values, and hippocampal volumetry data derived from the healthy controls sample of the ADNI database. We formed 4 groups of equal size (n=30) based on APOE4 carriage and amyloid-PET status. Baseline and followup (i.e., 48 months post-baseline) results indicated that Aβ-positivity was the most important factor to explain poorer cognitive performance, while APOE4 only exerted a signifcant efect in Aβ-positive subjects. Additionally, multiple regression analyses evidenced that, within the Aβ-positive sample, hippocampal volumetry explained most of the variability in cognitive performance for APOE4 carriers. These fndings represent a strong support for the so-called preclinical/prodromal hypothesis, which states that the reported diferences in cognitive performance between healthy carriers and non-carriers are mainly due to the APOE4’s capability to increase the risk of AD. Moreover, our results reinforce the notion that a synergistic interaction of Aβ and APOE4 elicits a neurodegenerative process in the hippocampus that might be the main cause of impaired cognitive performance.- Project number: 111
Item Aplicación de los juegos ¿Cuál es mi caso? y Koro como estrategias de enseñanza-aprendizaje de la Genética Básica y la Cardiogenética en el Grado de Medicina y Bachillerato(2020) Sacedón Ayuso, Rosa; Fraile Ramos, Alberto; Jiménez Pérez, Eva; Zuluaga Arias, María Del Pilar; Orera Clemente, María Asunción; Escribano Martínez, Catalina; López Blázquez, María; Medrano López, Constantino; Muñoz Delgado, Cecilia; Pujol de Castro, Antonio; Rodríguez Sánchez, BelénEn este trabajo hemos utilizado y mejorado dos "juegos serios", ¿Cuál es mi caso? y Koro, diseñados por nuestro equipo para promover el aprendizaje de la Genética orientada a la Medicina. El análisis de las encuestas de valoración completadas por los participantes, estudiantes de Medicina y Bachillerato, demuestra la eficacia y la eficacia de las mejoras realizadas y la idoneidad de ambos juegos independientemente de su nivel de estudios . El equipo, además propone una nueva versión del juego ¿Cuál es mi caso? con mayor nivel de dificultad donde se incluyen objetivos formativos nuevos. Item S-Adenosylmethionine Decreases Bacterial Translocation, Proinflammatory Cytokines, Oxidative Stress and Apoptosis Markers in Hepatic Ischemia-Reperfusion Injury in Wistar Rats(Antioxidants, 2023) Valdés, Sergio; Paredes Royano, Sergio Damián; García Carreras, Carmen; Zuluaga Arias, María Del Pilar; Rancán, Lisa; Linillos Pradillo, Beatriz; Arias Díaz, Javier; Vara Ameigeiras, Elena MaríaHepatic ischemia/reperfusion injury (IRI) can seriously impair liver function. It is initiated by oxidative stress, resulting in inflammation and apoptosis-induced cellular damage. Glutathione (GSH) prevents oxidative stress. S-Adenosylmethionine (SAMet) is a GSH synthesis precursor that avoids the deficit in SAMet-synthetase activity and contributes to intracellular ATP repletion. It also acts as a methyl group donor, stabilizing hepatocyte membranes, among other functions. This study investigated the effect of SAMet on bacterial translocation and levels of proinflammatory cytokines, oxidative stress and apoptosis markers in male Wistar rats subjected to hepatic IRI. Animals were randomly divided into six groups: (1) sham operation, (3) animals undergoing 60 min of ischemia of the right lateral lobe for temporary occlusion of the portal vein and hepatic artery plus 10 min of reperfusion, and (5) the same as (3) but with a reperfusion period of 120 min. Groups 2, 4 and 6, respectively, are the same as (1), (3) and (5), except that animals received SAMet (20 mg/kg) 15 min before ischemia. GSH, ATP, lipid peroxidation (LPO), TNF-α, IL-1β, IL-6, total caspase-1 and caspase-9, total and cleaved caspase-3, and phosphatidylcholine were determined in the liver. Endotoxin, TNF-α, IL-1β, IL-6, IL-10 and LPO in vena cava and portal vein blood samples were also measured. Endotoxin and LPO levels as well as proinflammatory cytokines and apoptotic markers increased significantly in animals undergoing IRI, both after 10 and 120 min of reperfusion. IRI produced a significant decrease in GSH, ATP, portal IL-10 and phosphatidylcholine. SAMet treatment prevented these effects significantly and increased survival rate. The study suggests that SAMet exerts protective effects in hepatic IRI.