Person:
Collado Yurrita, Luis Rodolfo

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First Name
Luis Rodolfo
Last Name
Collado Yurrita
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Medicina
Area
Medicina
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Now showing 1 - 6 of 6
  • Publication
    Metataxonomic and metabolomic evidence of biofilm homeostasis disruption related to caries: An in vitro study
    (Wiley, 2022-02-07) Sanchéz Beltran, Maria del Carmen; Velapatiño, Angela; Llama Palacios, Arancha; Valdés, Alberto; Cifuentes, Alejandro; Ciudad Cabañas, María José; Collado Yurrita, Luis Rodolfo
    The ecological dysbiosis of a biofilm includes not only bacterial changes but also changes in their metabolism. Related to oral biofilms, changes in metabolic activity are crucial endpoint, linked directly to the pathogenicity of oral diseases. Despite the advances in caries research, detailed microbial and metabolomic etiology is yet to be fully clarified. To advance this knowledge, a meta-taxonomic approach based on 16S rRNA gene sequencing and an untargeted metabolomic approach based on an ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry analysis (UHPLC/Q-TOF-MS) were conducted. To this end, an in vitro biofilm model derived from the saliva of healthy participants were developed, under commensal and cariogenic conditions by adding sucrose as the disease trigger. The cariogenic biofilms showed a significant increase of Firmicutes phyla (p = 0.019), due to the significant increase in the genus Streptococcus (p = 0.010), and Fusobacter (p < 0.001), by increase Fusobacterium (p < 0.001) and Sphingomonas (p = 0.024), while suffered a decrease in Actinobacteria (p < 0.001). As a consequence of the shift in microbiota composition, significant extracellular metabolomics changes were detected, showed 59 metabolites of the 120 identified significantly different in terms of relative abundance between the cariogenic/commensal biofilms (Rate of change > 2 and FDR < 0.05). Forty-two metabolites were significantly higher in abundance in the cariogenic biofilms, whereas 17 metabolites were associated significantly with the commensal biofilms, principally related protein metabolism, with peptides and amino acids as protagonists, latter represented by histidine, arginine, l-methionine, glutamic acid, and phenylalanine derivatives.
  • Publication
    Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends
    (MDPI, 2020-02-23) Puente Yagüe, Miriam de la; Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Cuadrado Cenzual, María Ángeles
    We are currently experiencing a vitamin D (VITD) deficiency pandemic across the world. Athletes have the same predisposition to low levels of vitamin D, the majority of its concentrations being below 20 ng/mL in a wide range of sports, especially in the winter months. Vitamin D is important in bone health, but recent research also points out its essential role in extraskeletal functions, including skeletal muscle growth, immune and cardiopulmonary functions and inflammatory modulation, which influence athletic performance. Vitamin D can also interact with extraskeletal tissues to modulate injury recovery and also influence the risk of infection. The data presented in this paper has triggered investigations in relation to the importance of maintaining adequate levels of vitamin D and to the possible positive influence supplementation has on immune and musculoskeletal functions in athletes, benefiting their performance and preventing future injuries. The objective of this review is to describe the latest research conducted on the epidemiology of vitamin D deficiency and its effects on sports performance and musculoskeletal health.
  • Publication
    Propuesta de un nuevo método de evaluación en asignaturas teórico-prácticas
    (2021-06-09) Pérez Castellano, Nicasio; Pérez-Villacastín Domínguez, Julián; Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; García Torrent, María Jesús; Llama Palacios, Maria Arantxazu; Puente Maestu, Luis; Sánchez Beltrán, María del Carmen; Moya Rueda, Ana Patricia; Marín Viecho, Julia; Roiz Sastrón, María del Carmen; Orozco Garduña, Josué; Torres Esquivel, Norberto; Flores Soler, Jesús Enrique
    Se presenta una propuesta de método de evaluación de los estudiantes de asignaturas eminentemente prácticas, especialmente de posgrado, basado en la valoración de la adquisición progresiva de conocimiento y habilidades en la práctica de la misma. El avance de los alumnos se evaluará mediante consecución de objetivos especificados y ajustados a fases crecientes de aptitud, debiendo superar una prueba teórica y de capacitación para subir a la siguiente fase. Lo más novedoso de este plan de evaluación es que los alumnos no serán valorados con las calificaciones tradicionales (Apto, Sobresaliente etc.) sino que la evaluación medirá la capacidad del alumno para desarrollar su trabajo en distintos entornos y con diferente nivel de responsabilidad, lo que también se debe reflejar en el título obtenido al final de sus estudios.
  • Publication
    Proyecto EVALUCA para el Fomento de la evaluacion de los sistemas de Calidad Universitarios
    (2018-09-24) Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Benito Leon, Julián; Hernandez Gallego, Jesús; Gomez Lus Centelles, María Luisa; Alou Cervera, Luis; Sevillano Fernandez, David; Cuadrado Cenzual, María Ángeles; Roiz Sastron, María del Carmen; Verdejo Bravo, Carlos; Madrigal Martínez Pereda, Cristina María; O´connor de la Oliva, Ana; Llama Palacios, María Aranzazu; Sánchez Beltrán, María del Carmen; Menchen Viso, Luis Alberto; Baca González, Laura; Serrano Sánchez, Victor; Vaello Checa, Iris; Marín Viecho, Julia; Córdoba Manzanares, María de los Ángeles; Conty de la Campa, Raquel; Ribeiro Vidal, Honorato José; San Mauro Martín, Ismael
    El Proyecto Evaluca (Evaluación de la Calidad) tiene como objetivo el desarrollo de herramientas que contribuyan al Fomento de la participacion de la Comunidad Universitaria (PDI, PAS, Estudiantes y Egresados) en la evaluación de la calidad.
  • Publication
    Curso de formación de profesorado en estructura departamental
    (2019-10-02) Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Hernández Gallego, Jesús; Gomez-Lus Centelles, Maria Luisa; Tejedor Jorge, Alberto; Madrigal Martinez-Pereda, Cristina María; Alou Cervera, Luis; Sevillano Fernandez, David; Benito León, Julián; Cuenca Caraballo, Maigualida; García Chacón, Marta; Oconnor de la Oliva, Anna; Marín Cuenda, María José; Roiz Sastrón, María del Carmen; San Mauro Martín, Ismael; Marín Viecho, Julia; Muñoz Lucas, María Angeles; Nieto Barbero, Maria Asunción; Callol Sánchez, Luis Miguel; Sanz Esporrín, Javier; García Torrent, María Jesús; Cuadrado Cenzual, María Ángeles
    El Proyecto propuesto es un Programa Formacion del Profesorado en Dirección y Gestión de Departamentos Universitarios dirigido al PDI, con apoyo del PAS, con la finalidad de obtener un cierto grado de profesionalización en Dirección Departamental.
  • Publication
    Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment
    (MDPI, 2018-04-03) San Mauro Martín, Ismael; Blumenfeld Olivares, Javier; Pérez Arruche, Eva; Arce Delgado, Esperanza; Ciudad Cabañas, María José; Garicano Vilar, Elena; Collado Yurrita, Luis Rodolfo
    Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women). Commercial milk, containing 2.24 g of sterols, was ingested daily during a 3-week period, and then the same amount of skim milk, without sterols, was consumed daily during the 3-week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Genes LIPC C-514T and APOA5 C56G are Ser19Trp carriers and greatly benefit from sterol intake in the diet. LIPC C-514T TT homozygous carriers had lower low-density lipoprotein cholesterol (LDL-c) levels than CC homozygote and CT heterozygote carriers after the ingestion of plant sterols (p = 0.001). These two genes also showed statistically significant changes in total cholesterol levels (p = 0.025; p = 0.005), and no significant changes in high-density lipoprotein (HDL) cholesterol levels (p = 0.032; p = 0.003), respectively. No statistically significant differences were observed for other genes. Further studies are needed to establish which genotype combinations would be the most protective against hypercholesterolemia.