RT Journal Article
T1 Gestation Food Restriction and Refeeding Compensate Maternal Energy Status and Alleviate Metabolic Consequences in Juvenile Offspring in a Rabbit Model
A1 García García, Rosa María
A1 Arias Álvarez, María
A1 Millán Pastor, María Pilar
A1 Rodríguez, María
A1 Sánchez Rodríguez, Ana
A1 Lorenzo González, Pedro Luis
A1 Rebollar, Pilar G.
AB Nutritional status during gestation can influence mother and offspring metabolism. Undernutrition in pregnancy affects women in both western and developing countries, and it is associated with a high prevalence of chronic diseases in later life. The present work was conducted in the rabbit model, as a longitudinal study, to examine the effect of food restriction during early and mid-gestation, and re-feeding ad libitum until the end of pregnancy on metabolic status and body reserves of mother and, its association with development and metabolism of fetuses and female offspring to the juvenile stage. Little changes in live body weight (LBW), compensatory feed intake, similar body reserves, and metabolism were observed in dams. Placenta biometry and efficiency were slightly affected, but fetal BW and phenotype were not modified. However, hyperinsulinemia, insulin resistance, and hypertriglyceridemia were demonstrated in pre-term fetuses. In the juvenile period, these changes were not evidenced, and a similar pattern of growth and serum metabolic parameters in offspring of food-restricted mothers were found, except in serum aminotransferases levels, which increased. These were associated with higher liver fibrosis. Maternal food restriction in the early and mid-pregnancy followed by re-feeding in our rabbit model established a compensatory energy status in dams and alleviated potential long-term consequences in growth and metabolism in the offspring, even if fetal metabolism was altered.
PB MPDI
SN 2072-6643
YR 2021
FD 2021-01-22
LK https://hdl.handle.net/20.500.14352/7387
UL https://hdl.handle.net/20.500.14352/7387
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (MCIU)
NO UCM funding for RESEARCH GROUPS
DS Docta Complutense
RD 4 abr 2025