%0 Journal Article
%A Rodríguez-Galán, Ana
%A Fernández Messina, Lola María
%A Sánchez-Madrid, Francisco
%T Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
%D 2018
%U https://hdl.handle.net/20.500.14352/97122
%X MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.
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