RT Journal Article
T1 Enhanced thermogenesis in PAS Kinase-deficient male mice
A1 Hurtado Carneiro, Verónica
A1 Juan Arévalo, Yolanda
A1 Flores, Cinthya N.
A1 Herrero De Dios, Carmen
A1 Pérez García, Ana
A1 Contreras Jiménez, Cristina
A1 López, Miguel
A1 Álvarez, Elvira
A1 Sanz Miguel, María Del Carmen
AB PAS domain-containing serine/threonine-protein kinase (PASK) is a nutrient and energy sensor regulated by fasting/refeeding conditions in hypothalamic areas involved in controlling energy balance. In this sense, PASK plays a role in coordinating the activation/inactivation of AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) in response to fasting. PASK deficiency protects against the development of diet-induced obesity. This has prompted an investigation into the potential role of PASK on energy expenditure through thermogenesis in adipose tissue. Our results indicate that PASK-deficient male mice exhibited higher brown adipose tissue (BAT) thermogenic activity and heat production. The inhibition of PASK function induces the expression of Uncoupling Protein 1 (UCP1) and the adipogenic marker peroxisome proliferator-activated receptor gamma (PPARγ) in BAT. In addition, PASK deficiency promotes the expression of UCP1 and other browning markers such as PR/SET Domain 16 (PRDM16) in inguinal white adipose tissue (WAT). PASK-deficient mice record an enhanced thermogenic response, even under stimuli such as β-3adrenergic receptor agonist or cold. This evidence reveals PASK as a new mechanism modulating BAT thermogenesis.
PB Elsevier
SN 0006-2952
YR 2025
FD 2025-01-15
LK https://hdl.handle.net/20.500.14352/116048
UL https://hdl.handle.net/20.500.14352/116048
LA eng
NO Hurtado-Carneiro V, Juan-Arevalo Y, Flores CN, Herrero-De-Dios C, Perez-Garcia A, Contreras C, Lopez M, Alvarez E, Sanz C. Enhanced thermogenesis in PAS Kinase-deficient male mice. Biochem Pharmacol. 2025 Jan 15;233:116757. doi: 10.1016/j.bcp.2025.116757. Epub ahead of print. PMID: 39824466.
NO Universidad Complutense de Madrid
NO Banco Santander
DS Docta Complutense
RD 6 abr 2025