RT Journal Article
T1 Metastatic outgrowth via the two-way interplay of autophagy and metabolism
A1 Barzegar Behrooz, Amir
A1 Cordani, Marco
A1 Donadelli, Massimo
A1 Ghavami, Saeid
AB Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, engage in dynamic dialogues with stromal cells and undertake epithelial-mesenchymal transition (EMT) phenoconversion. To ensure survival, tumor cells employ several strategies such as restructuring their metabolic needs to adapt to the alterations of the microenvironmental resources via different mechanisms including macroautophagy (autophagy) and to circumvent anoikis—a form of cell death induced upon detachment from the extracellular matrix (ECM). This review focuses on the puzzling connections of autophagy and energetic metabolism within the context of cancer metastasis.
PB Elsevier
SN 0925-4439
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/97772
UL https://hdl.handle.net/20.500.14352/97772
LA eng
NO Amir Barzegar Behrooz, Marco Cordani, Massimo Donadelli, Saeid Ghavami, Metastatic outgrowth via the two-way interplay of autophagy and metabolism, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, 166824, ISSN 0925-4439, https://doi.org/10.1016/j.bbadis.2023.166824.
NO Ministerio de Ciencia e Innovación (España)
NO University of Manitoba
NO European Commission
NO Ministry of Health (Italy)
NO CancerCare Manitoba Foundation
DS Docta Complutense
RD 12 abr 2025