RT Journal Article
T1 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells
A1 Reche Gallardo, Pedro Antonio
A1 Soumelis, Vassili
A1 Gorman, D M
A1 Clifford, T
A1 Liu, MR
A1 Travis, M
A1 Zurawski, Sandra M.
A1 Johnston, J
A1 Liu, Yong-Jun
A1 Spits, H
A1 Waal-Malefyt, Rene de
A1 Kastelein, Robert A.
A1 Bazan, Fernando
AB The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.
PB The American Association of Immunologists
SN 0022-1767
YR 2001
FD 2001
LK https://hdl.handle.net/20.500.14352/58252
UL https://hdl.handle.net/20.500.14352/58252
LA eng
DS Docta Complutense
RD 8 jun 2025