RT Journal Article
T1 Germacrone Derivatives as new Insecticidal and Acaricidal Compounds: A Structure-Activity Relationship
A1 Galisteo Pretel, Alberto
A1 Pérez del Pulgar, Helena
A1 Guerrero de León, Estela
A1 López-Pérez, José Luis
A1 Olmeda García, Ángeles Sonia
A1 Gonzalez-Coloma, Azucena
A1 Barrero, Alejandro
A1 Quílez del Moral, José Francisco
AB Currently, the use of synthetic pesticides is the main method of plant protection applied in agri- and horticulture. However, its excessive use leads to the development of pesticide resistance, a contamination of the environment, toxicity to non-target organisms, and risks for human health. With the ultimate aim of contributing to the develop of a more sustainable pest management, we used the natural product germacrone (compound 1), reported to possess significant insecticidal activity, as starting material for the generation of molecular diversity (2–24). Some of the generated derivatives are natural compounds, such as 1,10-epoxygermacrone (2), 4,5-epoxygermacrone (3), gajutsulactone A (7), germacrol (11), isogermacrone (14), 9-hydroxyeudesma-3,7(11)dien-6-one (19), eudesma-4,7(11),dien-8-one (20), eudesma-3,7(11)-dien-8-one (21) and eudesma-4(15),7(11)-dien-8-one (22). Compounds, 7,11-9,10-diepoxigermacr-4,5-en-8-ol (17), 7,11-epoxieudesma-4,7(11)-dien-8-one (23) and 7,11-epoxieudesma-3,7(11)-dien-8-one (24) are described for the first time. The biocidal activity of most of these compounds was assayed against the tick Hyalomma lusitanicum. The acaricidal effects of compound 24 were four times higher than that of germacrone (1). Compound 2 is an insect antifeedant a thousand times more potent than germacrone against Rhopalosiphum padi, which makes this substance a promising selective antifeedant against this cereal pest.
PB MDPI
SN 1420-3049
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/12528
UL https://hdl.handle.net/20.500.14352/12528
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
DS Docta Complutense
RD 7 abr 2025