RT Journal Article
T1 Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
A1 Ugalde Arbizu, Maider
A1 Aguilera Correa, John Jairo
A1 García Almodóvar, Victoria
A1 Ovejero Paredes, Karina
A1 Díaz García, Diana
A1 Esteban, Jaime
A1 Páez, Paulina L.
A1 Prashar, Sanjiv
A1 San Sebastián, Eider
A1 Filice, Marco
A1 Gómez Ruiz, Santiago
AB Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.
PB MDPI
SN 1999-4923
YR 2023
FD 2023-02-07
LK https://hdl.handle.net/20.500.14352/111913
UL https://hdl.handle.net/20.500.14352/111913
LA eng
NO Ugalde-Arbizu, M.; Aguilera-Correa, J.J.; GarcíaAlmodóvar, V.; Ovejero-Paredes, K.; Díaz-García, D.; Esteban, J.; Páez, P.L.; Prashar, S.; San Sebastian, E.; Filice, M.; et al. Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug. Pharmaceutics 2023, 15, 560. https://doi.org/10.3390/pharmaceutics15020560
NO 2023 Descuento MDPI
NO European Commission
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 23 abr 2025