RT Journal Article
T1 Cocoa flavanols protect human endothelial cells from oxidative stress
A1 Ferreira Martins, Tatian
A1 Palomino Ruiz-Poveda, Olga María
A1 Alvarez Cilleros, David
A1 Martín, María Angeles
A1 Ramos, Sonia
A1 Goya, Luis
AB Oxidative stress may cause functional disorders of vascular endothelia which can lead to endothelial apoptosis and thus alter the function and structure of the vascular tissues. Plant antioxidants protect the endothelium against oxidative stress and then become an effective option to treat vascular diseases. Cocoa flavanols have been proven to protect against oxidative stress in cell culture and animal models. In addition, epidemiological and interventional studies strongly suggest that cocoa consumption has numerous beneficial effects on cardiovascular health. The objective of this study was to test the chemo-protective effect of realistic concentrations of a cocoa phenolic extract and its main monomeric flavanol epicatechin on cultured human endothelial cells submitted to an oxidative challenge. Both products efficiently restrained stress-induced reactive oxygen species and biomarkers of oxidative stress such as carbonyl groups and malondialdehyde, and recovered depleted glutathione, antioxidant defences and cell viability. Our results demonstrate for the first time that a polyphenolic extract from cocoa and its main flavonoid protect human endothelial cells against an oxidative insult by modulating oxygen radical generation and antioxidant enzyme and non-enzyme defences.
PB Springer Nature
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/116358
UL https://hdl.handle.net/20.500.14352/116358
LA eng
NO Martins, T.F., Palomino, O.M., Álvarez-Cilleros, D. et al. Cocoa Flavanols Protect Human Endothelial Cells from Oxidative Stress. Plant Foods Hum Nutr 75, 161–168 (2020). https://doi.org/10.1007/s11130-020-00807-1
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 4 abr 2025