RT Journal Article
T1 Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression.
A1 González-Quevedo, Rosa
A1 Massa, Maria Jose
A1 P Iniesta, 
A1 Juan Chocano, María Del Carmen De
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Balibrea Cantero, José Luis
A1 Benito De Las Heras, Manuel R.
A1 Iniesta Serrano, María Pilar
AB We have evaluated telomerase activity in a tumour population of 65 human cancers by using a TRAP-based method, in which detection is performed by an enzyme immunoassay (ELISA). We have corroborated that sensitivity and specificity of this new procedure can be considered similar to that of classical TRAP method, having the advantage of a rapid and reproducible analysis of large pools of samples. Thus, telomerase activity was detected in 83% of the rumours included in our population. Moreover, we found a significant association between enzyme activity and both hTR and hTERT expression (P=0.004 and P=0.04, respectively).
PB SPANDIDOS PUBL LTD
SN 1019-6439
YR 2000
FD 2000-03-01
LK https://hdl.handle.net/20.500.14352/116259
UL https://hdl.handle.net/20.500.14352/116259
LA eng
NO González-Quevedo R, de Juan C, Massa MJ, Sánchez-Pernaute A, Torres A, Balibrea JL, Benito M, Iniesta P. Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression. Int J Oncol. 2000 Mar;16(3):623-8. doi: 10.3892/ijo.16.3.623. PMID: 10675498.
DS Docta Complutense
RD 10 abr 2025