RT Journal Article
T1 Application of Ligilactobacillus salivarius CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem
A1 Fernández Álvarez, Leonides
A1 Castro, Irma
A1 Arroyo Rodríguez, Rebeca
A1 Alba Rubio, Claudio
A1 Beltrán, David
A1 Rodríguez, Juan M.
AB In this study, the cervicovaginal environment of women with reproductive failure (repetitive abortion, infertility of unknown origin) was assessed and compared to that of healthy fertile women. Subsequently, the ability of Ligilactobacillus salivarius CECT5713 to increase pregnancy rates in women with reproductive failure was evaluated. Vaginal pH and Nugent score were higher in women with reproductive failure than in fertile women. The opposite was observed regarding the immune factors TGF-β 1, TFG-β 2, and VEFG. Lactobacilli were detected at a higher frequency and concentration in fertile women than in women with repetitive abortion or infertility. The metataxonomic study revealed that vaginal samples from fertile women were characterized by the high abundance of Lactobacillus sequences, while DNA from this genus was practically absent in one third of samples from women with reproductive failure. Daily oral administration of L. salivarius CECT5713 (~9 log10 CFU/day) to women with reproductive failure for a maximum of 6 months resulted in an overall successful pregnancy rate of 56%. The probiotic intervention modified key microbiological, biochemical, and immunological parameters in women who got pregnant. In conclusion, L. salivarius CECT5713 has proved to be a good candidate to improve reproductive success in women with reproductive failure.
PB MDPI
SN 2072-6643
YR 2021
FD 2021-01-06
LK https://hdl.handle.net/20.500.14352/7419
UL https://hdl.handle.net/20.500.14352/7419
LA eng
NO Contract 291-2018 established between Complutense University of Madrid and Biosearch Life S. A. (Granada, Spain)
NO Irma Castro is the recipient of a predoctoral contract (BES-2017-080713) from the Ministerio de Ciencia, Innovación y Universidades (Spain)
DS Docta Complutense
RD 14 may 2024