%0 Journal Article
%A Perdiguero Jiménez, Pedro
%A Martín-Martín, Alba
%A Benedicenti, Ottavia
%A Díaz-Rosales, Patricia
%A Morel, Esther
%A Muñoz Atienza, Estefanía
%A García-Flores, Mónica
%A Simón, Rocío
%A Soleto, Irene
%A Cerutti, Andrea
%A Tafalla, Carolina
%T Teleost IgD+IgM− B cells mount clonally expanded and mildly mutated intestinal IgD responses in the absence of lymphoid follicles
%D 2019
%@ 2211-1247
%U https://hdl.handle.net/20.500.14352/97047
%X Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM− plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the gut mucosa. Remarkably, secreted IgD binds to gut commensal bacteria, which in turn stimulate IgD gene transcription in gut B cells. Accordingly, secreted IgD from gut as well as gill mucosae, but not the spleen, show a V(D)J gene configuration consistent with microbiota-driven clonal expansion and diversification, including mild somatic hypermutation. By showing that secreted IgD establishes a mutualistic relationship with commensals, our findings suggest that secreted IgD may play an evolutionary conserved role in mucosal homeostasis.
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