RT Journal Article
T1 Teleost IgD+IgM− B cells mount clonally expanded and mildly mutated intestinal IgD responses in the absence of lymphoid follicles
A1 Perdiguero Jiménez, Pedro
A1 Martín-Martín, Alba
A1 Benedicenti, Ottavia
A1 Díaz-Rosales, Patricia
A1 Morel, Esther
A1 Muñoz Atienza, Estefanía
A1 García-Flores, Mónica
A1 Simón, Rocío
A1 Soleto, Irene
A1 Cerutti, Andrea
A1 Tafalla, Carolina
AB Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM− plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the gut mucosa. Remarkably, secreted IgD binds to gut commensal bacteria, which in turn stimulate IgD gene transcription in gut B cells. Accordingly, secreted IgD from gut as well as gill mucosae, but not the spleen, show a V(D)J gene configuration consistent with microbiota-driven clonal expansion and diversification, including mild somatic hypermutation. By showing that secreted IgD establishes a mutualistic relationship with commensals, our findings suggest that secreted IgD may play an evolutionary conserved role in mucosal homeostasis.
PB Elsevier
SN 2211-1247
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/97047
UL https://hdl.handle.net/20.500.14352/97047
LA eng
NO Perdiguero, Pedro, et al. «Teleost IgD+IgM− B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles». Cell Reports, vol. 29, n.o 13, diciembre de 2019, pp. 4223-4235.e5. https://doi.org/10.1016/j.celrep.2019.11.101.
NO AcknowledgmentsLucia González and Beatriz Abós are greatly acknowledged for technical assistance. This work was supported by the European Research Council (ERC Consolidator Grant 725061), the Spanish Ministry of Science, Innovation, and Universities (project AGL2017-85494-C2-1-R), and the Comunidad de Madrid (grant 2016-T1/BIO-1672).
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 6 abr 2025