RT Journal Article
T1 Vitamin C and vitamin C plus E improve the immune function in the elderly
A1 Fuente del Rey, Mónica de la
A1 Sánchez, Carmen
A1 Vallejo, Carmen
A1 Díaz del Cerro, Estefanía
A1 Arnalich, Francisco
A1 Hernanz, Ángel
AB With aging the immune response is impaired. This immunosenescence, in which an alteration of the redox state of the immune cells appears, is involved in the rate of aging. Since leukocyte function is a good marker of health and predictor of longevity, the effects of daily oral administration of the antioxidant vitamin C (500 mg), or both vitamin C (500 mg) and vitamin E (200 mg) on several blood neutrophil (adherence, chemotaxis, phagocytosis, and superoxide anion levels) and lymphocyte (adherence, chemotaxis, proliferation, interleukin-2 secretion and natural killer activity) functions were studied in healthy elderly men and women. These parameters were analysed before supplementation, after 3 months of supplementation, and 6 months after the end of supplementation. The results showed that vitamin C, in elderly participants, improved the immune functions studied which achieved values close to those of young adults. These effects were maintained in several functions after 6 months without supplementation. Similar effects were found in the elderly supplemented with both vitamin C and E. Thus, a short period of vitamin C or vitamin C and E ingestion, with the doses used, improves the immune function in elderly men and women and could contribute to a healthy longevity.
PB Elsevier
SN 0531-5565
YR 2020
FD 2020-10-19
LK https://hdl.handle.net/20.500.14352/7959
UL https://hdl.handle.net/20.500.14352/7959
LA eng
NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional (FEDER)
DS Docta Complutense
RD 11 abr 2025