RT Journal Article
T1 Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation
A1 Kurzbauer, Marie-Therese
A1 Pradillo Orellana, Mónica
A1 Kerzendorfer, Claudia
A1 Sims, Jason
A1 Ladurner, Rene
A1 Oliver, Cecilia
A1 Janisiw, Michael Peter
A1 Mosiolek, Magdalena
A1 Schweizer, Dieter
A1 Copenhaver, Gregory P.
A1 Schlögelhofer, Peter
AB Fanconi anemia (FA) is a human autosomal recessive disorder characterized by chromosomal instability, developmental pathologies, predisposition to cancer, and reduced fertility. So far, 19 genes have been implicated in FA, most of them involved in DNA repair. Some are conserved across higher eukaryotes, including plants. The Arabidopsis thaliana genome encodes a homolog of the Fanconi anemia D2 gene (FANCD2) whose function in DNA repair is not yet fully understood. Here, we provide evidence that AtFANCD2 is required for meiotic homologous recombination. Meiosis is a specialized cell division that ensures reduction of genomic content by half and DNA exchange between homologous chromosomes via crossovers (COs) prior to gamete formation. In plants, a mutation in AtFANCD2 results in a 14% reduction of CO numbers. Genetic analysis demonstrated that AtFANCD2 acts in parallel to both MUTS HOMOLOG4 (AtMSH4), known for its role in promoting interfering COs and MMS AND UV SENSITIVE81 (AtMUS81), known for its role in the formation of noninterfering COs. AtFANCD2 promotes noninterfering COs in a MUS81-independent manner and is therefore part of an uncharted meiotic CO-promoting mechanism, in addition to those described previously.
PB American Society of Plant Biologists
SN 1040-4651, ESSN: 1532-298X
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/18545
UL https://hdl.handle.net/20.500.14352/18545
LA eng
NO Unión Europea. FP7
NO Austrian Academy of Sciences
NO University of Vienna
NO Austrian Science Fund
DS Docta Complutense
RD 7 abr 2025