RT Journal Article
T1 Mortality from Parkinson's disease: A population-based prospective study (NEDICES)
A1 Posada Rodríguez, Ignacio Javier
A1 Benito León, Julián
A1 Louis, Elan
A1 Trincado, Rocío
A1 Villarejo Galende, Alberto
A1 Medrano, María José
A1 Bermejo Pareja, Félix
AB Most studies of mortality in Parkinson's disease have been clinical studies, yielding results that are not representative of the general population. We assessed the risk of mortality from Parkinson's disease in the Neurological Disorders in Central Spain (NEDICES) study, a prospective population-based study in which Parkinson's disease patients who were not ascertained through medical practitioners were also included. The cohort consisted of 5262 elderly subjects (mean baseline age, 73.0 years), including 81 with Parkinson's disease at baseline (1994–1995). Thirteen-year mortality was assessed. Two thousand seven hundred and one of 5262 subjects (51.3%) died over a median follow-up of 12.0 years (range, 0.04–14.8 years), including 66 of 81 subjects (81.5%) with Parkinson's disease at baseline and 2635 of 5181 subjects (50.8%) without Parkinson's disease at baseline. In an unadjusted Cox model, the hazard ratio of mortality was increased in subjects with Parkinson's disease (hazard ratio, 2.29; 95% confidence interval, 1.80–2.93; P < .001) versus subjects without Parkinson's disease (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, the risk of mortality remained elevated in subjects with Parkinson's disease (hazard ratio, 1.75; 95% CI, 1.32–2.31, P < .001). In additional Cox models, Parkinson's disease patients with dementia had particularly high risks of mortality (adjusted hazard ratio, 2.62; 95% CI, 1.40–4.90; P < .001). In this prospective population-based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality.
PB Wiley
SN 0885-3185
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/117590
UL https://hdl.handle.net/20.500.14352/117590
LA eng
NO Posada, I. J., Benito-León, J., Louis, E. D., Trincado, R., Villarejo, A., Medrano, M. J., & Bermejo-Pareja, F. (2011). Mortality from Parkinson's disease: a population-based prospective study (NEDICES). Movement disorders : official journal of the Movement Disorder Society, 26(14), 2522–2529. https://doi.org/10.1002/mds.23921
NO Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 8 abr 2025