RT Journal Article
T1 Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
A1 Gómez-Serrano, María
A1 Camafeita, Emilio
A1 García-Santos, Eva
A1 López, Juan
A1 Vázquez, Jesus
A1 Peral, Belen
A1 Rubio Herrera, Miguel Ángel
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
AB Obesity is a main global health issue and an outstanding cause of morbidity and mortality predisposing to type 2 diabetes (T2DM) and cardiovascular diseases. Huge research efforts focused on gene expression, cellular signalling and metabolism in obesity have improved our understanding of these disorders; nevertheless, to bridge the gap between the regulation of gene expression and changes in signalling/metabolism, protein levels must be assessed. We have extensively analysed visceral adipose tissue from age-, T2DM- and gender-matched obese patients using high-throughput proteomics and systems biology methods to identify new biomarkers for the onset of T2DM in obesity, as well as to gain insight into the influence of aging and gender in these disorders. About 250 proteins showed significant abundance differences in the age, T2DM and gender comparisons. In diabetic patients, remarkable gender-specific hallmarks were discovered regarding redox status, immune response and adipose tissue accumulation. Both aging and T2DM processes were associated with mitochondrial remodelling, albeit through well-differentiated proteome changes. Systems biology analysis highlighted mitochondrial proteins that could play a key role in the age-dependent pathophysiology of T2DM. Our findings could serve as a framework for future research in Translational Medicine directed at improving the quality of life of obese patients.
SN 2045-2322
YR 2016
FD 2016-05-10
LK https://hdl.handle.net/20.500.14352/116127
UL https://hdl.handle.net/20.500.14352/116127
LA eng
NO Gómez-Serrano M, Camafeita E, García-Santos E, López JA, Rubio MA, Sánchez- Pernaute A, Torres A, Vázquez J, Peral B. Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks. Sci Rep. 2016 May 10;6:25756. doi: 10.1038/srep25756. PMID: 27160966; PMCID: PMC4861930.
DS Docta Complutense
RD 7 abr 2025