RT Journal Article
T1 HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis
A1 Campillo, José
A1 Martínez-Escribano, José
A1 Muro, Manuel
A1 Moya Quiles, Rosa
A1 Marín, Luis
A1 Montes Ares, Olga
A1 Guerra Pérez, Natalia
A1 Sánchez Pedreño, Pedro
A1 Frías, José
A1 Lozano, José
A1 García Alonso, Ana
A1 Alvarez López, Rocío
AB Available data have led to a controversy on the relationship between human leukocyte antigen (HLA) and cutaneous malignant melanoma susceptibility or prognosis. Moreover, the influence of HLA-C on melanoma has not yet been well established. Therefore, the aim of the current study was to analyze the possible influence of the HLA system on melanoma susceptibility and prognosis in the Spanish population. For this purpose, HLA-A and HLA-B serotyping and HLA-C, HLA-DRB1, and HLA-DQB1 genotyping by polymerase chain reactions using sequence-specific oligonucleotide (PCR-SSO) and sequence-specific primer (PCR-SSP) were performed in 174 melanoma patients and 227 ethnically matched controls. The number of controls was increased up to 356 for HLA-C typing. Patients were stratified according to the histological subtypes of melanoma, sentinel lymph node status, tumor thickness, and ulceration of primary lesion. No HLA-A, HLA-B, HLA-DRB1, or HLA-DQB1 relationship with melanoma was observed for susceptibility or disease prognosis. However, the analysis of HLA-C locus showed that individuals homozygous for HLA-CLys80 were significantly more frequent within the patient than the control group. Remarkably, individuals homozygous for group 2 HLA-C alleles (HLA-CLys80) seem to be associated with metastatic progression of melanoma. In contrast, we found a negative association between group 1 HLA-C alleles (HLA-CAsn80) and disease susceptibility or metastasis development. In conclusion, although an association with HLA-A, HLA-B, HLA-DRB1, or HLA-DQB1 was not demonstrated, the study of the HLA-C locus revealed that the analysis of the dimorphism at position 80 in the α1 helix may help to evaluate the risk and prognosis of melanoma in our population.
PB Springer
SN 0093-7711
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/97965
UL https://hdl.handle.net/20.500.14352/97965
LA eng
NO Campillo, J.A., Martínez-Escribano, J.A., Muro, M. et al. HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. Immunogenetics 57, 926–933 (2006). https://doi.org/10.1007/s00251-005-0065-2
DS Docta Complutense
RD 7 abr 2025