RT Journal Article
T1 Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
A1 Tendilla Beltrán, Hiram
A1 Coatl Cuaya, Heriberto
A1 Meneses Prado, Silvia
A1 Vázquez Roque, Ruben Antonio
A1 Brambila, Eduardo
A1 Tapia Rodríguez, Miguel
A1 Martín Hernández, David
A1 Garcés Ramírez, Linda
A1 Muñoz Madrigal, José Luis
A1 Leza Cerro, Juan Carlos
A1 Flores, Gonzalo
AB Increased dopaminergic activity in the striatum underlies the neurobiology of psychotic symptoms in schizophrenia (SZ). Beyond the impaired connectivity among the limbic system, the excess of dopamine could lead to inflammation and oxidative/nitrosative stress. It has been suggested that atypical antipsychotic drugs attenuate psychosis not only due to their modulatory activity on the dopaminergic/serotonergic neurotransmission but also due to their anti-inflammatory/antioxidant effects. In such a manner, we assessed the effects of the atypical antipsychotic risperidone (RISP) on the structural neuroplasticity and biochemistry of the striatum in adult rats with neonatal ventral hippocampus lesion (NVHL), which is a developmental SZ-related model. RISP administration (0.25 mg/kg, i.p.) ameliorated the neuronal atrophy and the impairments in the morphology of the dendritic spines in the spiny projection neurons (SPNs) of the ventral striatum (nucleus accumbens: NAcc) in the NVHL rats. Also, RISP treatment normalized the pro-inflammatory pathways and induced the antioxidant activity of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in this model. Our results point to the neurotrophic, antiinflammatory, and antioxidant effects of RISP, together with its canonical antipsychotic mechanism, to enhance striatum function in animals with NVHL.
PB Elsevier
SN 0920-9964, ESSN: 1573-2509
YR 2021
FD 2021-07-20
LK https://hdl.handle.net/20.500.14352/4605
UL https://hdl.handle.net/20.500.14352/4605
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO CONACYT
DS Docta Complutense
RD 6 oct 2024