RT Journal Article
T1 Magnetotactic Bacteria Powered Biohybrids Target E. coli Biofilms
A1 Stanton, Morgan
A1 Park, Byung-Wook
A1 Vilela García, Diana
A1 Bente, Klaas
A1 Faivre, Damien
A1 Sitti, Metin
A1 Sánchez, Samuel
AB Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods includes the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the nonpathogenic magnetotactic bacteria Magnetosopirrillum gryphiswalense (MSR-1) can be integrated with drug-loaded mesoporous silica microtubes to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm. Applying external magnetic guidance capability and swimming power of the MSR-1 cells, the biohybrids are directed to and forcefully pushed into matured Escherichia coli (E. coli) biofilms. Release of the antibiotic, ciprofloxacin, is triggered by the acidic microenvironment of the biofilm, ensuring an efficient drug delivery system. The results reveal the capabilities of a nonpathogenic bacteria species to target and dismantle harmful biofilms, indicating biohybrid systems have great potential for antibiofilm applications.
PB American Chemical Society 
SN 1936-0851
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/94637
UL https://hdl.handle.net/20.500.14352/94637
LA eng
NO https://doi.org/10.1021/acsnano.7b04128
NO Stanton, Morgan M., et al. «Magnetotactic Bacteria Powered Biohybrids Target E. Coli Biofilms». ACS Nano, vol. 11, n.o 10, octubre de 2017, pp. 9968-78. https://doi.org/10.1021/acsnano.7b04128.
NO European Commission
NO Max Planck Society
NO Alexander von Humboldt Foundation
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 15 abr 2025