RT Journal Article
T1 Cerium  (III)  and  (IV)  contammg  mesoporous  glasses/alginate beads  for  bone  regeneration: Bioactivity,  biocompatibility  and reactive oxygen species activity.
A1 Varini, E.
A1 Sánchez Salcedo, Sandra
A1 Malavasi, Gianluca
A1 Lusvardi, Gigliola
A1 Vallet Regí, María Dulce Nombre
A1 Salinas Sánchez, Antonio Jesús
AB A very small  number  of biomaterials  investigated  for bone regeneration  was reported  as able to prevent the oxidative stress. In this study beads based on alginate hydrogel and mesoporous glasses (MG) containing different amounts of cerium oxides (Ce3+/Ce4+) exhibiting antioxidant  properties were investigated  as a good approach to mimic the action of antioxidant  enzymes in our organism. The effect of cerium contents on the bioactivity and biocompatibility of beads were investigated. Moreover,  the potential  capability of Ce-containing MG to prevent  the oxidative  stress caused bythe activity of reactive oxygen species (ROS) was here investigated for the first time. The increment of cerium oxide from 1.2, to 3.6 and 5.3 mol-% decreases the surface area and porosity of MG and increases the catalase mimetic activity after 168 h. Swelling tests in different cell culture media (D­ and  u-MEM)  demonstrated  the rehydration  capability  of  beads. The  presence  of  beads with  the highest Ce-contents  (3.6 and 5.3 %) improved the proliferation of pre-osteoblastic cells MC3T3-Cl cells. However, the cell differentiation decreased when increased the cerium content. Lactate dehydrogenase  assays showed beads are cytocompatible  materials. Moreover,  oxidative stress tests with H zO z showed a better response related to cell viability and the elimination  of oxidant species when  increased  cerium  content.  Beads  of  glasses  with  1.2  and  3.6  %  of  Ce02   are  excellent candidates as bioactive scaffolds for bone regeneration capable of counteract the oxidative stress.
PB Elsevier
SN 0928-4931
YR 2019
FD 2019-07-15
LK https://hdl.handle.net/20.500.14352/13464
UL https://hdl.handle.net/20.500.14352/13464
LA spa
NO Varini, E., Sánchez Salcedo, S., Malavasi, G. et al. «Cerium (III) and (IV) Containing Mesoporous Glasses/Alginate Beads for Bone Regeneration: Bioactivity, Biocompatibility and Reactive Oxygen Species Activity». Materials Science and Engineering: C, vol. 105, diciembre de 2019, p. 109971. DOI.org (Crossref), https://doi.org/10.1016/j.msec.2019.109971.
NO RESEARCHER ID N-4501-2014 (Sandra Sánchez Salcedo)ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID M-3316-2014 (Antonio Salinas Sánchez)ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
NO Unión Europea. H2020
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 6 abr 2025