RT Journal Article
T1 Determination of bioequivalence between generic and reference drugs using laser-induced breakdown spectroscopy
A1 Cárdenas Escudero, J.
A1 Cáceres, Jorge Omar
A1 Navarro Villoslada, Fernando
A1 Bellini, G.
A1 Galán Madruga, D.
A1 Cáceres, Jorge Omar
AB In vitro bioequivalence studies are strictly limited to the comparison of dissolution performance to a reference drug. These studies are performed without considering the chemical similarity between the generic and reference drug formulations. This work has focused on developing a groundbreaking method based on the laser-induced breakdown spectroscopy (LIBS) technique for the in vitro bioequivalence determination of immediate-release solid oral dosage form generic drugs and as an alternative method for establishing the biowaiver of in vivo generic drug studies.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/115750
UL https://hdl.handle.net/20.500.14352/115750
LA eng
NO J. Cardenas-Escudero, F. Navarro-Villoslada, G. Bellini, D. Galán-Madruga, J.O. Cáceres, Determination of bioequivalence between generic and reference drugs using laser-induced breakdown spectroscopy, Analytica Chimica Acta, Volume 1329, 2024, 343253, ISSN 0003-2670, https://doi.org/10.1016/j.aca.2024.343253.
NO Universidad de Panamá
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 6 abr 2025