RT Journal Article
T1 Analysis of the presence of cell proliferation-related molecules in the Tgf-β3 null mutant mouse palate reveals misexpression of EGF and Msx-1
A1 Del Río, A
A1 López-Gordillo, Y
A1 Martínez, M L
A1 Barrio Asensio, María Del Carmen
A1 Murillo Arroyo, Francisco Javier
A1 Maldonado Bautista, Estela
A1 Martínez Sanz, Elena
A1 Martínez Álvarez, María Concepción
AB The Tgf-β3 null mutant mouse palate presents several cellular anomalies that lead to the appearance of cleft palate. One of them concerns the cell proliferation of both the palatal medial edge epithelium and mesenchyme. In this work, our aim was to determine whether there was any variation in the presence/distribution of several cell proliferation-related molecules that could be responsible for the cell proliferation defects observed in these palates. Our results showed no difference in the presence of EGF-R, PDGF-A, TGF-β2, Bmp-2, and Bmp-4, and differences were minimal for FGF-10 and Shh. However, the expression of EGF and Msx-1 changed substantially. The shift of the EGF protein expression was the one that most correlated with that of cell proliferation. This molecule is regulated by TGF-β3, and experiments blocking its activity in culture suggest that EGF misexpression in the Tgf-β3 null mutant mouse palate plays a role in the cell proliferation defect observed.
PB KARGER
SN 1422-6405
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/101443
UL https://hdl.handle.net/20.500.14352/101443
LA eng
NO Del Rio, A., Barrio, M. C., Murillo, J., Maldonado, E., Lopez-Gordillo, Y., Martínez-Sanz, E., ... & Martinez-Alvarez, C. (2011). Analysis of the presence of cell proliferation-related molecules in the Tgf-β3 null mutant mouse palate reveals misexpression of EGF and Msx-1. Cells Tissues Organs, 193(3), 135-150.
NO Ministerio de Sanidad de España
NO Comunidad Autónoma de Madrid
NO Universidad Complutense con Banco Santander
DS Docta Complutense
RD 20 ago 2024