RT Journal Article
T1 Embryonal Rhabdomyosarcoma of the Tongue in Adults
A1 Díez Montiel, Alberto
A1 Antúnez Conde, Raúl
A1 Navarro Cuéllar, Carlos
A1 Tousidonis Rial, Manuel
A1 Salmerón Escobar, José Ignacio
A1 Bonsfils, Nuria
A1 Agra Pujol, Carolina
A1 Alijo Serrano, Francisco
A1 Ochandiano Caicoya, Santiago
AB Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the first two decades of life. One third of cases appear in the head and neck, with 60% of these being embryonal type. RMS is extremely rare in adults, comprising only 1% of adult malignancies, and of those, only 3.3% are rhabdomyosarcomas. (2) Case report: A 46 y.o. male presented with a 1 cm exophytic pediculated painless lesion on the dorsum of his tongue, with progressive growth for 3 months. An excisional biopsy revealed an “embryonal rhabdomyosarcoma with fusocellular areas, with negative rearrangement for gen FOXO1A, negative MDM2 (only focal positivity), and positive INI-1”. Subsequent contrast-enhanced MRI concluded the presence of a lesion with imprecise margins in the right half-tongue, 15 × 8 × 7 mm (longitudinal × transverse × craniocaudal), compatible with a sarcoma. The patient underwent a partial centrolingual glossectomy followed by reconstruction with a buccinator muscle local flap. After surgery, he received chemotherapy with eight cycles of VAC (vincristine, actinomycin, and cyclophosphamide) protocol. The patient is now disease free after 42 months, with good tongue function. (3) Discussion and conclusions: Embryonal RMS is an extremely rare sarcoma in adults, and the location in the tongue is even more exceptional (only two more similar cases are reported in the literature). The prognosis in adults is significantly poorer than in children. A complete margin-free resection with an adequate chemotherapy protocol is the treatment of choice in cases such as these.
PB MDPI
SN 2075-1729
YR 2023
FD 2023-05-25
LK https://hdl.handle.net/20.500.14352/107937
UL https://hdl.handle.net/20.500.14352/107937
LA eng
NO Díez-Montiel, A.; Antúnez-Conde, R.; Navarro Cuéllar, C.; Tousidonis Rial, M.; Salmerón, J.I.; Bonsfills, N.; Pujol, C.A.; Serrano, F.A.; Ochandiano, S. Embryonal Rhabdomyosarcoma of the Tongue in Adults. Life 2023, 13, 1255. https:// doi.org/10.3390/life13061255
NO Instituto de Salud Carlos III
NO Unión Europea
DS Docta Complutense
RD 9 abr 2025