RT Journal Article
T1 Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress
A1 Calmarza-Font, Isabel
A1 Lagunas García, Luisa Natalia
A1 Garcia-Segura, Luis
AB Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress.
PB Elsevier
SN 0166-4328
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/95507
UL https://hdl.handle.net/20.500.14352/95507
LA eng
NO Calmarza-Font I, Lagunas N, Garcia-Segura LM. Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress. Behav Brain Res. 2012 Feb 1;227(1):287-90. doi: 10.1016/j.bbr.2011.10.036. Epub 2011 Oct 29. PMID: 22061801.
DS Docta Complutense
RD 9 abr 2025