RT Journal Article
T1 Influence of the APOE ε4 allele and mild cognitive impairment diagnosis in the disruption of the MEG resting state functional connectivity in sources space
A1 Cuesta Prieto, Pablo
A1 Garcés, Pilar
A1 Castellanos, Nazareth P
A1 López García, María Eugenia
A1 Aurtenetxe, Sara
A1 Bajo, Ricardo
A1 Pineda-Pardo, José Angel
A1 Bruña Fernández, Ricardo
A1 Marín, Antonio García
A1 Delgado Losada, María Luisa
A1 Barabash Bustelo, Ana
A1 Ancín, Inés
A1 Cabranes Díaz, José Antonio
A1 Fernández Lucas, Alberto Amable
A1 del Pozo, Francisco
A1 Sancho Ruiz, Miguel
A1 Marcos Dolado, Alberto
A1 Nakamura, Akinori
A1 Maestu Unturbe, Fernando
AB The apolipoprotein E (APOE) ε4 allele constitutes the major genetic risk for the development of late onset Alzheimer's disease (AD). However, its influence on the neurodegeneration that occurs in early AD remains unresolved. In this study, the resting state magnetoencephalography(MEG) recordings were obtained from 27 aged healthy controls and 36 mild cognitive impairment (MCI) patients. All participants were divided into carriers and non-carriers of the ε4 allele. We have calculated the functional connectivity (FC) in the source space along brain regions estimated using the Harvard-Oxford atlas and in the classical bands. Then, a two way ANOVA analysis (diagnosis and APOE) was performed in each frequency band. The diagnosis effect consisted of a diminished FC within the high frequency bands in the MCI patients, affecting medial temporal and parietal regions. The APOE effect produced a decreased long range FC in delta band in ε4 carriers. Finally, the interaction effect showed that the FC pattern of the right frontal-temporal region could be reflecting a compensatory/disruption process within the ε4 allele carriers. Several of these results correlated with cognitive decline and neuropsychological performance. The present study characterizes how the APOE ε4 allele and MCI status affect the brain's functional organization by analyzing the FC patterns in MEG resting state in the sources space. Therefore a combination of genetic, neuropsychological, and neurophysiological information might help to detect MCI patients at higher risk of conversion to AD and asymptomatic subjects at higher risk of developing a manifest cognitive deterioration.
PB IOS Press
SN 1387-2877
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/100214
UL https://hdl.handle.net/20.500.14352/100214
LA eng
NO Cuesta, Pablo et al. ‘Influence of the APOE Ε4 Allele and Mild Cognitive Impairment Diagnosis in the Disruption of the MEG Resting State Functional Connectivity in Sources Space’. 1 Jan. 2015 : 493 – 505.
DS Docta Complutense
RD 5 abr 2025