RT Journal Article
T1 Dental Biofilm Removal and Bacterial Contamination of a New Doubled-Side Thermoplastic Polyurethane-Based Toothbrush: A Crossover Study in Healthy Volunteers
A1 Zúñiga Uhalde, Ignacio
A1 Iniesta Albentosa, Margarita Isabel
A1 Virto Ruiz, Leire
A1 Ribeiro Vida, Honorato José
A1 Alonso Español, Andrea
A1 Hernández Ruiz de Azcárate, Fernando
A1 Cardona Álvarez, John Jairo
A1 Maher Lavandero, Anushiravan
A1 Alonso Álvarez, Bettina María
A1 Sanz Alonso, Mariano
A1 Herrera González, David
AB Multiple toothbrush designs have been developed to enhance dental biofilm removal and decrease bacterial contamination and retention over time. Therefore, the aim of this clinical study was to compare the efficacy of a prototype of a new double-sided thermoplastic polyurethane-based toothbrush with that of a conventional nylon-bristle toothbrush. A crossover study was conducted in systemically healthy volunteers (n = 24) for two one-week periods plus one washout week. As outcome variables, plaque and gingival indices, total bacterial contamination of the toothbrushes by quantitative polymerase chain reaction (qPCR), and patient-reported outcomes were measured. Clinical and microbiological variables were analysed using a general linear model and Friedman and Wilcoxon signed-rank tests. No statistically significant differences between toothbrushes were detected neither for full-mouth PlI (p > 0.05) nor for GI (p > 0.05). Similarly, no statistically significant differences were detected for bacterial contamination after 40 seconds or 1 week of use, with results expressed either in CFU/mL or in CFU/mm2 (p > 0.05). In conclusion, the tested prototype toothbrush was as effective and safe as the control toothbrush, and the participating subjects did not experience any adverse effects from its use and rated its efficiency and effectiveness in cleaning their teeth as satisfactory.
PB MDPI
SN 2079-6382
YR 2022
FD 2022-09-22
LK https://hdl.handle.net/20.500.14352/73273
UL https://hdl.handle.net/20.500.14352/73273
LA eng
NO Zúñiga, I.; Iniesta, M.; Virto, L.; Ribeiro-Vidal, H.; Alonso-Español, A.; Hernández, F.; Cardona, J.J.; Maher-Lavandero, A.; Alonso, B.; Sanz, M.; et al. Dental Biofilm Removal and Bacterial Contamination of a New Doubled-Side Thermoplastic Polyurethane-Based Toothbrush: A Crossover Study in Healthy Volunteers. Antibiotics 2022, 11, 1296, doi:10.3390/antibiotics11101296.
NO Received: 23 August 2022; Accepted: 19 September 2022;  Published: 22 September 2022
NO Universidad Complutense de Madrid (España)
NO Ziz Dental Care SL (España)
DS Docta Complutense
RD 16 jun 2025