RT Journal Article
T1 Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease
A1 Sánchez Cebrián, Juan Domingo
A1 Alcántara León, Andrés Rafael
A1 González Matilla, Juan Francisco
A1 Sánchez Montero, José
AB IntroductionAlzheimer’s disease is a multifactorial neurodegenerative disorder characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The disease involves interconnected mechanisms, which can be clustered into two target-packs based on the affected proteins. Pack-1 focuses on beta-amyloid accumulation, oxidative stress, and metal homeostasis dysfunction, and Pack-2 involves tau protein, calcium homeostasis, and neuroinflammation. Against this background heterocyclic system, there is a powerful source of pharmacophores to develop effective small drugs to treat multifactorial diseases like Alzheimer’s.Areas coveredThis review highlights the most promising heterocyclic systems as potential hit candidates with multi-target capacity for the development of new drugs targeting Alzheimer’s disease. The selection of these heterocyclic systems was based on two crucial factors: their synthetic versatility and their well-documented biological properties of therapeutic potential in neurodegenerative diseases.Expert opinionThe synthesis of small drugs against Alzheimer’s disease requires a multifactorial approach that targets the key pathological proteins. In this context, the utilization of heterocyclic systems, with well-established synthetic processes and facile functionalization, becomes a crucial element in the design phases. Furthermore, the selection of hit heterocyclic should be guided by a full understanding of their biological activities. Thus, the identification of promising heterocyclic scaffolds with known biological effects increases the potential to develop effective molecules against Alzheimer’s disease.
PB Taylor and Francis
SN 1746-0441
YR 2023
FD 2023-11-01
LK https://hdl.handle.net/20.500.14352/92498
UL https://hdl.handle.net/20.500.14352/92498
LA eng
NO Sánchez, Juan D, Alcántara, Andrés R, González, Juan F, Sánchez-Montero, José María.Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease, Expert Opinion on Drug Discovery, Noviembre 2023 18:12, 1413-28, DOI: 10.1080/17460441.2023.2264766
NO Este artículo fue solicitado por encargo al autor sin costes adicionales basado en la experiencia del autor sobre el tema.
DS Docta Complutense
RD 1 sept 2024