RT Journal Article
T1 Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies
A1 Jover, Rodrigo
A1 Herreros De Tejada López, Albe
A1 Marín Gabriel, José Carlos
A1 Fernández Díez, Servando
A1 Morillas, Juan D.
A1 Castells, Antoni
AB Background: Adenoma detection rate (ADR) has become the most important quality indicator for colonoscopy. Objective: The aim of this study was to investigate which modifiable factors, directly related to the endoscopic procedure, influenced the ADR in screening colonoscopies. Design: Observational, nested study. Setting: Multicenter, randomized, controlled trials. Patients: Asymptomatic people aged 50 to 69 years were eligible for a multicenter, randomized, controlled trial designed to compare colonoscopy and fecal immunochemical testing in colorectal cancer screening. A total of 4539 individuals undergoing a direct screening colonoscopy were included in this study. Intervention: Colonoscopy. Main Outcome Measurements: Bowel cleansing, sedation, withdrawal time in normal colonoscopies, and cecal intubation were analyzed as possible predictors of adenoma detection by using logistic regression analysis, adjusted for age and sex. Results: In multivariate analysis, after adjustment for age and sex, factors independently related to the ADR were a mean withdrawal time longer than 8 minutes (odds ratio [OR] 1.51; 95% CI, 1.17-1.96) in normal colonoscopies and split preparation (OR 1.26; 95% CI, 1.01-1.57). For advanced adenomas, only withdrawal time maintained statistical significance in the multivariate analysis. For proximal adenomas, withdrawal time and cecal intubation maintained independent statistical significance, whereas only withdrawal time longer than 8 minutes and a <10-hour period between the end of preparation and colonoscopy showed independent associations for distal adenomas. Limitations: Only endoscopic variables have been analyzed. Conclusion: Withdrawal time was the only modifiable factor related to the ADR in colorectal cancer screening colonoscopies associated with an increased detection rate of overall, advanced, proximal, and distal adenomas. © 2013 American Society for Gastrointestinal Endoscopy.
PB Elsevier
SN 1097-6779
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/130607
UL https://hdl.handle.net/20.500.14352/130607
LA eng
NO Jover R, Zapater P, Polanía E, Bujanda L, Lanas A, Hermo JA, Cubiella J, Ono A, González-Méndez Y, Peris A, Pellisé M, Seoane A, Herreros-de-Tejada A, Ponce M, Marín-Gabriel JC, Chaparro M, Cacho G, Fernández-Díez S, Arenas J, Sopeña F, de-Castro L, Vega-Villaamil P, Rodríguez-Soler M, Carballo F, Salas D, Morillas JD, Andreu M, Quintero E, Castells A; COLONPREV study investigators. Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies. Gastrointest Endosc. 2013 Mar;77(3):381-389.e1. doi: 10.1016/j.gie.2012.09.027. Epub 2012 Dec 4. PMID: 23218945.
NO This work was supported by grants from Asociación Española de Gastroenterología
NO Asociación Española contra el Cáncer (Fundación Científica and Junta de Barcelona)
NO Instituto de Salud Carlos III (PI08/90717, PI08/0726, INT-09/208, PI11/2630)
NO Agència de Gestió d’Ajuts Universitaris i de Recerca (2009SGR849)
NO FEDER funds
DS Docta Complutense
RD 21 ago 2026