RT Journal Article
T1 Does admission acetylsalicylic acid uptake in hospitalized COVID‑19 patients have a protective role? Data from the Spanish SEMI‑COVID‑19 Registry
A1 Formiga, Francesc
A1 Méndez Bailón, Manuel
A1 García Sánchez, Francisco Javier
A1 Lumbreras Bermejo, Carlos Juan
A1 Millán Núñez-Cortés, Jesús
A1 Lalueza Blanco, Antonio
A1 Maestro De La Calle, Guillermo
A1 Lora-Tamayo Morillo-Velarde, Jaime
A1 Ordieres Ortega, Lucía
A1 Estrada Pérez, Vicente
A1 Pérez-Somarriba Moreno, María Del Juncal
A1 Ramos Rincón, Jose Manuel
AB Acetylsalicylic acid (ASA) is widely used in the treatment and prevention of cardiovascular disorders. Our objective is to evaluate its possible protective role, not only in mortality but also in other aspects such as inflammation, symptomatic thrombosis, and intensive care unit (ICU) admission in hospitalized COVID-19 patients. We realized an observational retrospective cohort study of 20,641 patients with COVID-19 pneumonia collected and followed-up from Mar 1st, 2020 to May 1st, 2021, from the nationwide Spanish SEMI-COVID-19 Registry. Propensity score matching (PSM) was performed to determine whether treatment with ASA affected outcomes in COVID-19 patients. On hospital admission, 3291 (15.9%) patients were receiving ASA. After PSM, 3291 patients exposed to ASA and 2885 not-exposed patients were analyzed. In-hospital mortality was higher in the ASA group (30.4 vs. 16.9%, p < 0.001) in the global sample. After PSM, no differences were found between groups (30.4 vs. 30.3%, p = 0.938). There were no differences in inflammation, symptomatic thrombosis, or ICU admission. In conclusion, ASA intake is not associated with in-hospital mortality or any other health outcome evaluated after applying PSM analysis in a real-world large sample of hospitalized COVID-19 patients.
PB Springer Nature
YR 2021
FD 2021-11-29
LK https://hdl.handle.net/20.500.14352/122297
UL https://hdl.handle.net/20.500.14352/122297
LA eng
NO Formiga F, Rubio-Rivas M, Mora-Luján JM, Escudero SC, Martinez RFM, Mendez-Bailón M, et al. Does admission acetylsalicylic acid uptake in hospitalized COVID-19 patients have a protective role? Data from the Spanish SEMI-COVID-19 Registry. Intern Emerg Med 2022;17:761–75. https://doi.org/10.1007/s11739-021-02870-1
DS Docta Complutense
RD 17 jul 2025