%0 Journal Article
%A Sánchez Salcedo, Sandra
%A Malavasi, Gianluca
%A Salinas Sánchez, Antonio J.
%A Lusvardi, Gigliola
%A Rigamonti, Luca
%A Menabue, Ledi
%A Vallet Regí, María Dulce Nombre
%T Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
%D 2018
%@ 1996-1944
%U https://hdl.handle.net/20.500.14352/11980
%X Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol%) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1, x = 80, y = 12, z = 3 for Ga_2 and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses allow determining that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of P. aeruginosa bacteria demonstrating its potential for tissue engineering applications.
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