RT Journal Article
T1 Trehalose and Dry Eye Disease: A Comprehensive Systematic Review of Randomized Controlled Trials
A1 Ballesteros Sánchez, Antonio
A1 Martínez Pérez, Clara
A1 Álvarez Peregrina, Cristina
A1 Sánchez Tena, Miguel Ángel
A1 De Hita Cantalejo, Concepción
A1 Sánchez González, María Carmen
A1 Sánchez González, María Carmen
AB The purpose of the research project was to extensively review the efficacy and safety of a trehalose tear-substitute treatment in cases of dry eye disease (DED). A systematic review that included only full-length randomized controlled studies (RCTs) reporting the effects of trehalose tear-substitute treatment in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement. The search period included papers published before 8 August 2023. The Cochrane risk-of-bias tool was used to analyze the quality of the studies selected. A total of 10 RCTs were included in this systematic review. Trehalose tear-substitute treatments achieved a higher improvement than did control group interventions in all reported variables. The mean differences between both groups were in favor of trehalose, and were as follows: ocular surface disease index (OSDI) questionnaire score of −8.5 ± 7 points, tear film breakup time (TBUT) of 1.9 ± 1 s, tear film thickness (TFT) of 0.25 ± 0.1 μm, tear meniscus height (TMH) of 0.02 ± 0.02 mm, Schirmer test (ST) of 0.8 ± 1.4 mm, corneal fluorescein staining (CFS) of −0.7 ± 0.1 points and visual acuity (VA) of 0.3 ± 2.1 letters. No adverse events after trehalose tear-substitute treatments were reported. Trehalose tear substitutes are a safe and effective treatment for DED. Therefore, trehalose tear substitutes should be recommended for patients with dry eye disease. In addition, there is specific evidence to support its use in the preoperative cataract surgery period.
PB MDPI
SN 2077-0383
YR 2023
FD 2023-11-25
LK https://hdl.handle.net/20.500.14352/103614
UL https://hdl.handle.net/20.500.14352/103614
LA eng
NO Ballesteros-Sánchez, A.; Martinez-Perez, C.; Alvarez- Peregrina, C.; Sánchez-Tena, M.Á.; De-Hita-Cantalejo, C.; Sánchez- González, M.C.; Sánchez-González, J.-M. Trehalose and Dry Eye Disease: A Comprehensive Systematic Review of Randomized Controlled Trials. J. Clin. Med. 2023, 12, 7301. https:// doi.org/10.3390/jcm12237301
DS Docta Complutense
RD 17 dic 2025