RT Journal Article
T1 Chaperone-mediated autophagy regulates adipocyte differentiation
A1 Macho González, Adrián
A1 Kaushik, Susmita
A1 Juste, Yves
A1 Lindenau, Kristen
A1 Dong, Suxhian
A1 Santiago-Fernández, Olaya
A1 McCabe, Mericka
A1 Singh, Rajat
A1 Gavathiotis, Evris
A1 Cuervo, Ana María
AB Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis is its transcriptional regulation through timely expression and silencing of a vast number of genes. However, whether turnover of key regulatory proteins per se controls adipogenesis remains largely understudied. Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation that, in response to diverse cues, remodels the proteome for regulatory purposes. We report here the activation of CMA during adipocyte differentiation and show that CMA regulates adipogenesis at different steps through timely degradation of key regulatory signaling proteins and transcription factors that dictate proliferation, energetic adaptation, and signaling changes required for adipogenesis.
PB Science
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/116187
UL https://hdl.handle.net/20.500.14352/116187
LA eng
NO Kaushik, Susmita, et al. «Chaperone-Mediated Autophagy Regulates Adipocyte Differentiation». Science Advances, vol. 8, n.o 46, noviembre de 2022, p. eabq2733. DOI.org (Crossref), https://doi.org/10.1126/sciadv.abq2733.
NO Ministerio de Ciencia e Innovacion (España) – Margarita Salas fellowship
NO National Institutes of Health (EE.UU)
NO JPB Foundation
NO The Glenn Foundation
NO The Grace Science Foundation
DS Docta Complutense
RD 9 abr 2025